I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| smooth muscle cell | 24 studies | 39% ± 17% | |
| pericyte | 12 studies | 42% ± 20% | |
| cardiac muscle cell | 7 studies | 61% ± 17% | |
| myofibroblast cell | 3 studies | 36% ± 15% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| smooth muscle cell | 24 studies | 39% ± 17% | |
| pericyte | 12 studies | 42% ± 20% | |
| cardiac muscle cell | 7 studies | 61% ± 17% | |
| myofibroblast cell | 3 studies | 36% ± 15% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| heart | 6 studies | 26% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 31% | 1717.27 | 77 / 245 | 96% | 22.86 | 481 / 502 |
| intestine | 71% | 8734.95 | 687 / 966 | 54% | 8.76 | 284 / 527 |
| uterus | 88% | 8605.07 | 150 / 170 | 25% | 20.58 | 115 / 459 |
| esophagus | 60% | 7066.99 | 874 / 1445 | 49% | 12.05 | 90 / 183 |
| bladder | 57% | 3773.05 | 12 / 21 | 50% | 9.77 | 253 / 504 |
| blood vessel | 100% | 36000.47 | 1330 / 1335 | 0% | 0 | 0 / 0 |
| heart | 97% | 51513.05 | 836 / 861 | 0% | 0 | 0 / 0 |
| muscle | 96% | 14539.59 | 770 / 803 | 0% | 0 | 0 / 0 |
| stomach | 33% | 2502.60 | 119 / 359 | 59% | 15.46 | 170 / 286 |
| lung | 13% | 571.82 | 74 / 578 | 67% | 12.70 | 779 / 1155 |
| breast | 15% | 760.90 | 70 / 459 | 60% | 5.43 | 670 / 1118 |
| kidney | 8% | 387.99 | 7 / 89 | 67% | 22.63 | 604 / 901 |
| pancreas | 0% | 0 | 0 / 328 | 72% | 13.09 | 129 / 178 |
| thymus | 9% | 519.31 | 62 / 653 | 51% | 3.88 | 306 / 605 |
| adrenal gland | 1% | 30.94 | 2 / 258 | 43% | 10.74 | 100 / 230 |
| adipose | 39% | 2180.73 | 468 / 1204 | 0% | 0 | 0 / 0 |
| ovary | 17% | 1341.66 | 31 / 180 | 17% | 1.69 | 73 / 430 |
| brain | 0% | 14.57 | 8 / 2642 | 32% | 5.09 | 228 / 705 |
| eye | 0% | 0 | 0 / 0 | 33% | 8.33 | 26 / 80 |
| skin | 2% | 81.04 | 30 / 1809 | 19% | 6.78 | 88 / 472 |
| tonsil | 0% | 0 | 0 / 0 | 11% | 2.53 | 5 / 45 |
| liver | 0% | 0 | 0 / 226 | 11% | 1.56 | 44 / 406 |
| spleen | 0% | 11.43 | 1 / 241 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_1901020 | Biological process | negative regulation of calcium ion transmembrane transporter activity |
| GO_0051480 | Biological process | regulation of cytosolic calcium ion concentration |
| GO_1902081 | Biological process | negative regulation of calcium ion import into sarcoplasmic reticulum |
| GO_0086092 | Biological process | regulation of the force of heart contraction by cardiac conduction |
| GO_0046716 | Biological process | muscle cell cellular homeostasis |
| GO_0007219 | Biological process | Notch signaling pathway |
| GO_0051924 | Biological process | regulation of calcium ion transport |
| GO_0086004 | Biological process | regulation of cardiac muscle cell contraction |
| GO_0051926 | Biological process | negative regulation of calcium ion transport |
| GO_1901894 | Biological process | regulation of ATPase-coupled calcium transmembrane transporter activity |
| GO_1901897 | Biological process | regulation of relaxation of cardiac muscle |
| GO_0010459 | Biological process | negative regulation of heart rate |
| GO_0002026 | Biological process | regulation of the force of heart contraction |
| GO_0006874 | Biological process | intracellular calcium ion homeostasis |
| GO_0055119 | Biological process | relaxation of cardiac muscle |
| GO_0032780 | Biological process | negative regulation of ATP-dependent activity |
| GO_0090281 | Biological process | negative regulation of calcium ion import |
| GO_0043086 | Biological process | negative regulation of catalytic activity |
| GO_0010881 | Biological process | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion |
| GO_0086023 | Biological process | adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process |
| GO_0001675 | Biological process | acrosome assembly |
| GO_1901877 | Biological process | negative regulation of calcium ion binding |
| GO_0008015 | Biological process | blood circulation |
| GO_1901895 | Biological process | negative regulation of ATPase-coupled calcium transmembrane transporter activity |
| GO_0048738 | Biological process | cardiac muscle tissue development |
| GO_0086036 | Biological process | regulation of cardiac muscle cell membrane potential |
| GO_0008016 | Biological process | regulation of heart contraction |
| GO_0090534 | Cellular component | calcium ion-transporting ATPase complex |
| GO_0048471 | Cellular component | perinuclear region of cytoplasm |
| GO_0016020 | Cellular component | membrane |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0005739 | Cellular component | mitochondrion |
| GO_0031966 | Cellular component | mitochondrial membrane |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0016529 | Cellular component | sarcoplasmic reticulum |
| GO_0033017 | Cellular component | sarcoplasmic reticulum membrane |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0004857 | Molecular function | enzyme inhibitor activity |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0042030 | Molecular function | ATPase inhibitor activity |
| GO_0051117 | Molecular function | ATPase binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | PLN |
| Protein name | Cardiac phospholamban (PLB) |
| Synonyms | hCG_20805 PLB |
| Description | FUNCTION: Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+) . Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation. Controls intracellular Ca(2+) levels in elongated spermatids. May play a role in germ cell differentiation (By similarity). . FUNCTION: Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. . |
| Accessions | P26678 ENST00000357525.6 Q5R352 |
