PLIN5 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PLIN5 at tissue level.

III. Associated gene sets

GO_0060192Biological processnegative regulation of lipase activity
GO_0031999Biological processnegative regulation of fatty acid beta-oxidation
GO_0010890Biological processpositive regulation of sequestering of triglyceride
GO_0010897Biological processnegative regulation of triglyceride catabolic process
GO_0032000Biological processpositive regulation of fatty acid beta-oxidation
GO_0060193Biological processpositive regulation of lipase activity
GO_2000378Biological processnegative regulation of reactive oxygen species metabolic process
GO_0010867Biological processpositive regulation of triglyceride biosynthetic process
GO_0035359Biological processnegative regulation of peroxisome proliferator activated receptor signaling pathway
GO_0019915Biological processlipid storage
GO_0034389Biological processlipid droplet organization
GO_0051646Biological processmitochondrion localization
GO_0010884Biological processpositive regulation of lipid storage
GO_0005811Cellular componentlipid droplet
GO_0005739Cellular componentmitochondrion
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0035473Molecular functionlipase binding

IV. Literature review

[source]
Gene namePLIN5
Protein namePerilipin-5 (Lipid storage droplet protein 5)
Perilipin 5
SynonymsLSDP5
OXPAT
PAT-1
DescriptionFUNCTION: Lipid droplet-associated protein that maintains the balance between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to the surface of lipid droplets and is involved in lipid droplet homeostasis by regulating both the storage of fatty acids in the form of triglycerides and the release of fatty acids for mitochondrial fatty acid oxidation. In lipid droplet triacylglycerol hydrolysis, plays a role as a scaffolding protein for three major key lipolytic players: ABHD5, PNPLA2 and LIPE. Reduces the triacylglycerol hydrolase activity of PNPLA2 by recruiting and sequestering PNPLA2 to lipid droplets. Phosphorylation by PKA enables lipolysis probably by promoting release of ABHD5 from the perilipin scaffold and by facilitating interaction of ABHD5 with PNPLA2. Also increases lipolysis through interaction with LIPE and upon PKA-mediated phosphorylation of LIPE (By similarity). .

AccessionsQ00G26
ENST00000586133.1
ENST00000381848.7
K7EIX1
ENST00000592610.1