PLEKHO1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008360Biological processregulation of cell shape
GO_0007520Biological processmyoblast fusion
GO_0051451Biological processmyoblast migration
GO_0072673Biological processlamellipodium morphogenesis
GO_1901739Biological processregulation of myoblast fusion
GO_0032587Cellular componentruffle membrane
GO_0036195Cellular componentmuscle cell projection membrane
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePLEKHO1
Protein namePleckstrin homology domain-containing family O member 1 (PH domain-containing family O member 1) (C-Jun-binding protein) (JBP) (Casein kinase 2-interacting protein 1) (CK2-interacting protein 1) (CKIP-1) (Osteoclast maturation-associated gene 120 protein)
Pleckstrin homology domain containing O1 (Pleckstrin homology domain containing, family O member 1)
Pleckstrin homology domain containing, family O member 1
SynonymsHQ0024c
OC120
hCG_39382
RP11-458I7.3-002
RP11-458I7.3-007
CKIP1
DescriptionFUNCTION: Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation. .

AccessionsQ5T4P8
ENST00000369124.5 [Q53GL0-1]
Q5T4P9
Q53GL0
ENST00000369126.5