Name | Number of supported studies | Average coverage | |
---|---|---|---|
macrophage | 27 studies | 31% ± 11% | |
conventional dendritic cell | 21 studies | 36% ± 15% | |
smooth muscle cell | 19 studies | 29% ± 13% | |
B cell | 18 studies | 26% ± 8% | |
classical monocyte | 17 studies | 32% ± 15% | |
dendritic cell | 16 studies | 37% ± 24% | |
monocyte | 15 studies | 29% ± 10% | |
non-classical monocyte | 15 studies | 34% ± 19% | |
pericyte | 13 studies | 29% ± 14% | |
myeloid cell | 10 studies | 32% ± 13% | |
microglial cell | 9 studies | 26% ± 9% | |
plasmacytoid dendritic cell | 9 studies | 28% ± 8% | |
naive B cell | 7 studies | 22% ± 6% | |
fibroblast | 7 studies | 20% ± 4% | |
leukocyte | 6 studies | 31% ± 8% | |
platelet | 6 studies | 40% ± 13% | |
mononuclear phagocyte | 6 studies | 32% ± 15% | |
myofibroblast cell | 6 studies | 24% ± 7% | |
memory B cell | 6 studies | 22% ± 5% | |
endothelial cell | 6 studies | 32% ± 10% | |
endothelial cell of vascular tree | 5 studies | 19% ± 3% | |
gamma-delta T cell | 4 studies | 26% ± 10% | |
naive thymus-derived CD4-positive, alpha-beta T cell | 3 studies | 24% ± 3% | |
effector memory CD8-positive, alpha-beta T cell | 3 studies | 27% ± 2% | |
hematopoietic precursor cell | 3 studies | 31% ± 11% | |
megakaryocyte | 3 studies | 30% ± 4% | |
tissue-resident macrophage | 3 studies | 30% ± 15% | |
intermediate monocyte | 3 studies | 36% ± 26% | |
natural killer cell | 3 studies | 17% ± 2% | |
neuron | 3 studies | 28% ± 12% | |
connective tissue cell | 3 studies | 20% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
lung | 99% | 4170.15 | 571 / 578 | 98% | 24.75 | 1135 / 1155 |
ovary | 98% | 3102.18 | 176 / 180 | 99% | 22.65 | 426 / 430 |
uterus | 99% | 5535.40 | 168 / 170 | 98% | 39.16 | 448 / 459 |
prostate | 97% | 5742.82 | 237 / 245 | 98% | 19.92 | 491 / 502 |
adrenal gland | 100% | 4517.45 | 257 / 258 | 95% | 19.77 | 218 / 230 |
bladder | 100% | 11581.52 | 21 / 21 | 94% | 24.28 | 475 / 504 |
breast | 93% | 2653.99 | 427 / 459 | 99% | 26.44 | 1109 / 1118 |
brain | 92% | 3321.59 | 2436 / 2642 | 100% | 36.47 | 704 / 705 |
intestine | 93% | 14628.27 | 898 / 966 | 86% | 12.80 | 451 / 527 |
esophagus | 83% | 12085.56 | 1206 / 1445 | 85% | 12.92 | 156 / 183 |
thymus | 64% | 1353.07 | 416 / 653 | 95% | 22.18 | 572 / 605 |
skin | 46% | 1022.23 | 837 / 1809 | 98% | 34.66 | 464 / 472 |
kidney | 56% | 1201.34 | 50 / 89 | 88% | 20.19 | 795 / 901 |
stomach | 59% | 5597.68 | 211 / 359 | 85% | 15.53 | 244 / 286 |
lymph node | 0% | 0 | 0 / 0 | 100% | 134.33 | 29 / 29 |
spleen | 100% | 7276.15 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 25.87 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 27.36 | 1 / 1 |
blood vessel | 100% | 8941.83 | 1334 / 1335 | 0% | 0 | 0 / 0 |
pancreas | 1% | 23.58 | 4 / 328 | 97% | 27.47 | 172 / 178 |
adipose | 96% | 3185.33 | 1152 / 1204 | 0% | 0 | 0 / 0 |
peripheral blood | 96% | 5118.18 | 888 / 929 | 0% | 0 | 0 / 0 |
heart | 89% | 3173.76 | 767 / 861 | 0% | 0 | 0 / 0 |
liver | 5% | 114.00 | 12 / 226 | 75% | 11.30 | 304 / 406 |
muscle | 75% | 2173.87 | 602 / 803 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 56% | 6.89 | 45 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0008360 | Biological process | regulation of cell shape |
GO_0007520 | Biological process | myoblast fusion |
GO_0051451 | Biological process | myoblast migration |
GO_0072673 | Biological process | lamellipodium morphogenesis |
GO_1901739 | Biological process | regulation of myoblast fusion |
GO_0032587 | Cellular component | ruffle membrane |
GO_0036195 | Cellular component | muscle cell projection membrane |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0005515 | Molecular function | protein binding |
Gene name | PLEKHO1 |
Protein name | Pleckstrin homology domain-containing family O member 1 (PH domain-containing family O member 1) (C-Jun-binding protein) (JBP) (Casein kinase 2-interacting protein 1) (CK2-interacting protein 1) (CKIP-1) (Osteoclast maturation-associated gene 120 protein) Pleckstrin homology domain containing O1 (Pleckstrin homology domain containing, family O member 1) Pleckstrin homology domain containing, family O member 1 |
Synonyms | HQ0024c OC120 hCG_39382 RP11-458I7.3-002 RP11-458I7.3-007 CKIP1 |
Description | FUNCTION: Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation. . |
Accessions | Q5T4P8 ENST00000369124.5 [Q53GL0-1] Q5T4P9 Q53GL0 ENST00000369126.5 |