PLEKHM2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032880Biological processregulation of protein localization
GO_0007030Biological processGolgi organization
GO_0032418Biological processlysosome localization
GO_0042267Biological processnatural killer cell mediated cytotoxicity
GO_0010008Cellular componentendosome membrane
GO_0005765Cellular componentlysosomal membrane
GO_0005515Molecular functionprotein binding
GO_0019894Molecular functionkinesin binding

IV. Literature review

[source]
Gene namePLEKHM2
Protein namePleckstrin homology and RUN domain containing M2
Pleckstrin homology domain-containing family M member 2 (PH domain-containing family M member 2) (Salmonella-induced filaments A and kinesin-interacting protein) (SifA and kinesin-interacting protein)
SynonymsKIAA0842
SKIP
DescriptionFUNCTION: Plays a role in lysosomes movement and localization at the cell periphery acting as an effector of ARL8B. Required for ARL8B to exert its effects on lysosome location, recruits kinesin-1 to lysosomes and hence direct their movement toward microtubule plus ends. Binding to ARL8B provides a link from lysosomal membranes to plus-end-directed motility . Critical factor involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells . Required for maintenance of the Golgi apparatus organization . May play a role in membrane tubulation . .

AccessionsENST00000375799.8 [Q8IWE5-1]
A0A2R8Y575
ENST00000375793.2 [Q8IWE5-2]
Q8IWE5
ENST00000642363.1