Name | Number of supported studies | Average coverage | |
---|---|---|---|
macrophage | 12 studies | 26% ± 8% | |
endothelial cell | 8 studies | 25% ± 6% | |
myeloid cell | 8 studies | 25% ± 10% | |
microglial cell | 7 studies | 22% ± 7% | |
fibroblast | 6 studies | 22% ± 9% | |
classical monocyte | 4 studies | 25% ± 7% | |
glutamatergic neuron | 4 studies | 40% ± 23% | |
epithelial cell | 4 studies | 30% ± 11% | |
cardiac muscle cell | 4 studies | 18% ± 2% | |
astrocyte | 4 studies | 27% ± 7% | |
GABAergic neuron | 3 studies | 38% ± 16% | |
oligodendrocyte precursor cell | 3 studies | 25% ± 5% | |
alveolar macrophage | 3 studies | 31% ± 12% | |
oligodendrocyte | 3 studies | 18% ± 1% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 5 studies | 30% ± 14% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 6399.04 | 1445 / 1445 | 100% | 78.41 | 183 / 183 |
skin | 100% | 8163.87 | 1809 / 1809 | 100% | 116.85 | 472 / 472 |
uterus | 100% | 6639.29 | 170 / 170 | 100% | 71.06 | 459 / 459 |
brain | 100% | 12275.36 | 2640 / 2642 | 100% | 103.13 | 705 / 705 |
lung | 100% | 9533.31 | 578 / 578 | 100% | 62.17 | 1154 / 1155 |
thymus | 100% | 6078.86 | 652 / 653 | 100% | 71.17 | 605 / 605 |
ovary | 100% | 6387.12 | 180 / 180 | 100% | 62.98 | 429 / 430 |
prostate | 100% | 6218.57 | 245 / 245 | 99% | 54.78 | 499 / 502 |
kidney | 100% | 4694.31 | 89 / 89 | 99% | 52.45 | 895 / 901 |
stomach | 100% | 4456.67 | 359 / 359 | 99% | 49.21 | 284 / 286 |
intestine | 100% | 5719.22 | 966 / 966 | 99% | 45.13 | 523 / 527 |
breast | 100% | 6722.95 | 459 / 459 | 99% | 52.70 | 1109 / 1118 |
bladder | 100% | 6424.90 | 21 / 21 | 99% | 58.83 | 499 / 504 |
adrenal gland | 100% | 6935.78 | 258 / 258 | 98% | 38.33 | 226 / 230 |
pancreas | 96% | 3071.11 | 314 / 328 | 100% | 62.10 | 178 / 178 |
liver | 90% | 2084.00 | 204 / 226 | 95% | 28.20 | 385 / 406 |
adipose | 100% | 7755.36 | 1204 / 1204 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 121.85 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 87.61 | 29 / 29 |
muscle | 100% | 15181.01 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 8448.43 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 77.96 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 42.58 | 1 / 1 |
blood vessel | 100% | 7259.53 | 1333 / 1335 | 0% | 0 | 0 / 0 |
heart | 99% | 6970.93 | 854 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 98% | 4984.05 | 910 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0032880 | Biological process | regulation of protein localization |
GO_0007030 | Biological process | Golgi organization |
GO_0032418 | Biological process | lysosome localization |
GO_0042267 | Biological process | natural killer cell mediated cytotoxicity |
GO_0010008 | Cellular component | endosome membrane |
GO_0005765 | Cellular component | lysosomal membrane |
GO_0005515 | Molecular function | protein binding |
GO_0019894 | Molecular function | kinesin binding |
Gene name | PLEKHM2 |
Protein name | Pleckstrin homology and RUN domain containing M2 Pleckstrin homology domain-containing family M member 2 (PH domain-containing family M member 2) (Salmonella-induced filaments A and kinesin-interacting protein) (SifA and kinesin-interacting protein) |
Synonyms | KIAA0842 SKIP |
Description | FUNCTION: Plays a role in lysosomes movement and localization at the cell periphery acting as an effector of ARL8B. Required for ARL8B to exert its effects on lysosome location, recruits kinesin-1 to lysosomes and hence direct their movement toward microtubule plus ends. Binding to ARL8B provides a link from lysosomal membranes to plus-end-directed motility . Critical factor involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells . Required for maintenance of the Golgi apparatus organization . May play a role in membrane tubulation . . |
Accessions | ENST00000375799.8 [Q8IWE5-1] A0A2R8Y575 ENST00000375793.2 [Q8IWE5-2] Q8IWE5 ENST00000642363.1 |