PLEKHA3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042147Biological processretrograde transport, endosome to Golgi
GO_0008150Biological processbiological_process
GO_0007032Biological processendosome organization
GO_0001881Biological processreceptor recycling
GO_0005802Cellular componenttrans-Golgi network
GO_0000139Cellular componentGolgi membrane
GO_0005829Cellular componentcytosol
GO_0005794Cellular componentGolgi apparatus
GO_0055037Cellular componentrecycling endosome
GO_0005769Cellular componentearly endosome
GO_0070273Molecular functionphosphatidylinositol-4-phosphate binding
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePLEKHA3
Protein namePleckstrin homology domain-containing family A member 3 (PH domain-containing family A member 3) (Phosphatidylinositol-four-phosphate adapter protein 1) (FAPP-1) (Phosphoinositol 4-phosphate adapter protein 1)
Pleckstrin homology domain containing A3
SynonymsFAPP1
DescriptionFUNCTION: Plays a role in regulation of vesicular cargo transport from the trans-Golgi network (TGN) to the plasma membrane . Regulates Golgi phosphatidylinositol 4-phosphate (PtdIns(4)P) levels and activates the PtdIns(4)P phosphatase activity of SACM1L when it binds PtdIns(4)P in 'trans' configuration . Binds preferentially to PtdIns(4)P . Negatively regulates APOB secretion from hepatocytes . .

AccessionsH7C0Q0
Q9HB20
ENST00000234453.10
F8WCR7
ENST00000453653.5
ENST00000421187.1