PLA2G6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0019731Biological processantibacterial humoral response
GO_0006935Biological processchemotaxis
GO_0035774Biological processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
GO_2000304Biological processpositive regulation of ceramide biosynthetic process
GO_0034638Biological processphosphatidylcholine catabolic process
GO_0046338Biological processphosphatidylethanolamine catabolic process
GO_0035965Biological processcardiolipin acyl-chain remodeling
GO_0046473Biological processphosphatidic acid metabolic process
GO_0046469Biological processplatelet activating factor metabolic process
GO_0032049Biological processcardiolipin biosynthetic process
GO_0038096Biological processFc-gamma receptor signaling pathway involved in phagocytosis
GO_0005615Cellular componentextracellular space
GO_0005886Cellular componentplasma membrane
GO_0005739Cellular componentmitochondrion
GO_0016607Cellular componentnuclear speck
GO_0005829Cellular componentcytosol
GO_0015630Cellular componentmicrotubule cytoskeleton
GO_0031143Cellular componentpseudopodium
GO_0052816Molecular functionlong-chain fatty acyl-CoA hydrolase activity
GO_0004623Molecular functionphospholipase A2 activity
GO_0047499Molecular functioncalcium-independent phospholipase A2 activity
GO_0017171Molecular functionserine hydrolase activity
GO_0016787Molecular functionhydrolase activity
GO_0042802Molecular functionidentical protein binding
GO_0004622Molecular functionlysophospholipase activity
GO_0102545Molecular functionphosphatidyl phospholipase B activity
GO_0003847Molecular function1-alkyl-2-acetylglycerophosphocholine esterase activity
GO_0005516Molecular functioncalmodulin binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePLA2G6
Protein namePhospholipase A2 group VI
85/88 kDa calcium-independent phospholipase A2 (CaI-PLA2) (EC 3.1.1.4) (2-lysophosphatidylcholine acylhydrolase) (EC 3.1.1.5) (Group VI phospholipase A2) (GVI PLA2) (Intracellular membrane-associated calcium-independent phospholipase A2 beta) (iPLA2-beta) (Palmitoyl-CoA hydrolase) (EC 3.1.2.2) (Patatin-like phospholipase domain-containing protein 9) (PNPLA9)
phospholipase A2 (EC 3.1.1.4)
SynonymsPLPLA9
DescriptionFUNCTION: Calcium-independent phospholipase involved in phospholipid remodeling with implications in cellular membrane homeostasis, mitochondrial integrity and signal transduction. Hydrolyzes the ester bond of the fatty acyl group attached at sn-1 or sn-2 position of phospholipids (phospholipase A1 and A2 activity respectively), producing lysophospholipids that are used in deacylation-reacylation cycles . Hydrolyzes both saturated and unsaturated long fatty acyl chains in various glycerophospholipid classes such as phosphatidylcholines, phosphatidylethanolamines and phosphatidates, with a preference for hydrolysis at sn-2 position . Can further hydrolyze lysophospholipids carrying saturated fatty acyl chains (lysophospholipase activity) . Upon oxidative stress, contributes to remodeling of mitochondrial phospholipids in pancreatic beta cells, in a repair mechanism to reduce oxidized lipid content . Preferentially hydrolyzes oxidized polyunsaturated fatty acyl chains from cardiolipins, yielding monolysocardiolipins that can be reacylated with unoxidized fatty acyls to regenerate native cardiolipin species (By similarity). Hydrolyzes oxidized glycerophosphoethanolamines present in pancreatic islets, releasing oxidized polyunsaturated fatty acids such as hydroxyeicosatetraenoates (HETEs) (By similarity). Has thioesterase activity toward fatty-acyl CoA releasing CoA-SH known to facilitate fatty acid transport and beta-oxidation in mitochondria particularly in skeletal muscle . Plays a role in regulation of membrane dynamics and homeostasis. Selectively hydrolyzes sn-2 arachidonoyl group in plasmalogen phospholipids, structural components of lipid rafts and myelin (By similarity). Regulates F-actin polymerization at the pseudopods, which is required for both speed and directionality of MCP1/CCL2-induced monocyte chemotaxis . Targets membrane phospholipids to produce potent lipid signaling messengers. Generates lysophosphatidate (LPA, 1-acyl-glycerol-3-phosphate), which acts via G-protein receptors in various cell types (By similarity). Has phospholipase A2 activity toward platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine), likely playing a role in inactivation of this potent pro-inflammatory signaling lipid (By similarity). In response to glucose, amplifies calcium influx in pancreatic beta cells to promote INS secretion (By similarity). .; FUNCTION: [Isoform Ankyrin-iPLA2-1]: Lacks the catalytic domain and may act as a negative regulator of the catalytically active isoforms. .; FUNCTION: [Isoform Ankyrin-iPLA2-2]: Lacks the catalytic domain and may act as a negative regulator of the catalytically active isoforms. .

AccessionsENST00000427114.6
ENST00000663895.1 [O60733-1]
A0A590UK67
ENST00000594306.1
ENST00000673413.1
A0A590UK51
ENST00000454670.1
O60733
ENST00000668949.1
A0A590UJZ2
M0R3D9
ENST00000668499.1
A0A3Q9WQR3
ENST00000667521.1 [O60733-1]
B0QYE9
A0A590UJH4
ENST00000448094.5
ENST00000452542.5
ENST00000332509.8 [O60733-1]
ENST00000436218.6
H0Y6T3
H7C3P5
ENST00000664587.1
A0A3T0ZC00
M0R1Q9
ENST00000498338.1
ENST00000660610.1 [O60733-1]
ENST00000430886.5
H0Y7G5
F8WEQ9
ENST00000665987.1
ENST00000655142.1
ENST00000335539.7 [O60733-2]
F8WEN3
ENST00000402064.5 [O60733-2]
E7EX67
A0A3S5IBI3
ENST00000455341.2
A0A590UJC7
A0A3T0ZC14