PKDCC report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0048566Biological processembryonic digestive tract development
GO_0001501Biological processskeletal system development
GO_0015031Biological processprotein transport
GO_0018108Biological processpeptidyl-tyrosine phosphorylation
GO_0032332Biological processpositive regulation of chondrocyte differentiation
GO_0035264Biological processmulticellular organism growth
GO_0048286Biological processlung alveolus development
GO_0060021Biological processroof of mouth development
GO_0030154Biological processcell differentiation
GO_0030501Biological processpositive regulation of bone mineralization
GO_0030282Biological processbone mineralization
GO_0042997Biological processnegative regulation of Golgi to plasma membrane protein transport
GO_0035108Biological processlimb morphogenesis
GO_0005576Cellular componentextracellular region
GO_0005794Cellular componentGolgi apparatus
GO_0004715Molecular functionnon-membrane spanning protein tyrosine kinase activity
GO_0005524Molecular functionATP binding
GO_0004672Molecular functionprotein kinase activity

IV. Literature review

[source]
Gene namePKDCC
Protein nameProtein kinase domain containing, cytoplasmic
Extracellular tyrosine-protein kinase PKDCC (EC 2.7.10.2) (Protein kinase domain-containing protein, cytoplasmic) (Protein kinase-like protein SgK493) (Sugen kinase 493) (Vertebrate lonesome kinase)
SynonymsSGK493
VLK
DescriptionFUNCTION: Secreted tyrosine-protein kinase that mediates phosphorylation of extracellular proteins and endogenous proteins in the secretory pathway, which is essential for patterning at organogenesis stages. Mediates phosphorylation of MMP1, MMP13, MMP14, MMP19 and ERP29 . Probably plays a role in platelets: rapidly and quantitatively secreted from platelets in response to stimulation of platelet degranulation . May also have serine/threonine protein kinase activity. Required for longitudinal bone growth through regulation of chondrocyte differentiation. May be indirectly involved in protein transport from the Golgi apparatus to the plasma membrane (By similarity). .

AccessionsENST00000401498.6
ENST00000294964.6
Q504Y2
F8WB71