PIWIL1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PIWIL1 at tissue level.

III. Associated gene sets

GO_0007283Biological processspermatogenesis
GO_0141006Biological processpiRNA-mediated retrotransposon silencing by heterochromatin formation
GO_0140990Biological processprimary piRNA processing
GO_0006417Biological processregulation of translation
GO_0051321Biological processmeiotic cell cycle
GO_0031047Biological processregulatory ncRNA-mediated gene silencing
GO_0035092Biological processsperm DNA condensation
GO_0007286Biological processspermatid development
GO_0034587Biological processpiRNA processing
GO_0043186Cellular componentP granule
GO_0033391Cellular componentchromatoid body
GO_0097433Cellular componentdense body
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0140262Molecular functionmRNA cap binding complex binding
GO_0004521Molecular functionRNA endonuclease activity
GO_0003727Molecular functionsingle-stranded RNA binding
GO_0019901Molecular functionprotein kinase binding
GO_0003729Molecular functionmRNA binding
GO_0034584Molecular functionpiRNA binding
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePIWIL1
Protein namePiwi-like protein 1 (EC 3.1.26.-)
Piwi like RNA-mediated gene silencing 1 (Piwi-like protein 1)
SynonymsHIWI
DescriptionFUNCTION: Endoribonuclease that plays a central role in postnatal germ cells by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Strongly prefers a uridine in the first position of their guide (g1U preference, also named 1U-bias). Not involved in the piRNA amplification loop, also named ping-pong amplification cycle. Acts as an endoribonuclease that cleaves transposon messenger RNAs. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation. Probable component of some RISC complex, which mediates RNA cleavage and translational silencing. Also plays a role in the formation of chromatoid bodies and is required for some miRNAs stability. Required to sequester RNF8 in the cytoplasm until late spermatogenesis; RNF8 being released upon ubiquitination and degradation of PIWIL1. .; FUNCTION: [Isoform 3]: May be a negative developmental regulator . .

AccessionsENST00000633252.1
ENST00000613226.2 [Q96J94-1]
ENST00000634115.1
ENST00000539400.5
F5GYG0
ENST00000245255.7 [Q96J94-1]
ENST00000535956.5
F5H3U6
ENST00000539995.5
F5H2F7
Q96J94
ENST00000632888.1 [Q96J94-2]
ENST00000542723.1
ENST00000633272.1
ENST00000633042.1
ENST00000634077.1
F5GZL9
ENST00000546060.5
F5H889