PITX3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PITX3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PITX3 at tissue level.

III. Associated gene sets

GO_0014014Biological processnegative regulation of gliogenesis
GO_0009887Biological processanimal organ morphogenesis
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0035902Biological processresponse to immobilization stress
GO_0071542Biological processdopaminergic neuron differentiation
GO_0043525Biological processpositive regulation of neuron apoptotic process
GO_1990792Biological processcellular response to glial cell derived neurotrophic factor
GO_0042220Biological processresponse to cocaine
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0006355Biological processregulation of DNA-templated transcription
GO_0009653Biological processanatomical structure morphogenesis
GO_0002088Biological processlens development in camera-type eye
GO_0002089Biological processlens morphogenesis in camera-type eye
GO_1904935Biological processpositive regulation of cell proliferation in midbrain
GO_1904313Biological processresponse to methamphetamine hydrochloride
GO_0030901Biological processmidbrain development
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_1990837Molecular functionsequence-specific double-stranded DNA binding

IV. Literature review

[source]
Gene namePITX3
Protein namePituitary homeobox 3
Pituitary homeobox 3 (Homeobox protein PITX3) (Paired-like homeodomain transcription factor 3)
Paired-like homeodomain-3
SynonymsPTX3
DescriptionFUNCTION: Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. In addition to its importance during development, it also has roles in the long-term survival and maintenance of the mdDA neurons. Activates NR4A2/NURR1-mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state. Essential for the normal lens development and differentiation. Plays a critical role in the maintenance of mitotic activity of lens epithelial cells, fiber cell differentiation and in the control of the temporal and spatial activation of fiber cell-specific crystallins. Positively regulates FOXE3 expression and negatively regulates PROX1 in the anterior lens epithelium, preventing activation of CDKN1B/P27Kip1 and CDKN1C/P57Kip2 and thus maintains lens epithelial cells in cell cycle (By similarity). .

AccessionsA0A127AXK3
A0A0B5HFC8
A0A0C5G9P5
A0A0C5GCA9
A0A0C5G2Q9
A0A0B5HSU7
A0A0B5HLB1
A0A0B5HP26
A0A223LNB8
A0A0B5HFD9
A0A223LNB9
A0A0C5GPM3
A0A0B5HBG5
A0A0B5HFD3
A0A0B5HP33
O75364
A0A0C5G9P0
A0A0B5HFC0
ENST00000370002.8
A0A0C5GCA6
A0A0B5HBE9
A0A0B5HBF7
A0A0B5HLC0
A0A0C5GDS1
A0A0B5HLB6
A0A0C5GDS2
A0A223LNP9
A0A0B5HSV2
A0A0B5HSV6
A0A0B5HP44
A0A0B5HLA6
A0A0B5HP39