I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| ciliated cell | 9 studies | 33% ± 15% | |
| deuterosomal cell | 4 studies | 24% ± 6% | |
| epithelial cell | 4 studies | 21% ± 4% | |
| non-classical monocyte | 3 studies | 30% ± 12% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| ciliated cell | 9 studies | 33% ± 15% | |
| deuterosomal cell | 4 studies | 24% ± 6% | |
| epithelial cell | 4 studies | 21% ± 4% | |
| non-classical monocyte | 3 studies | 30% ± 12% |
Insufficient scRNA-seq data for expression of PITPNM1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| thymus | 100% | 4276.76 | 652 / 653 | 99% | 33.56 | 600 / 605 |
| lung | 100% | 3935.18 | 576 / 578 | 98% | 32.45 | 1130 / 1155 |
| brain | 98% | 5927.99 | 2595 / 2642 | 99% | 24.07 | 697 / 705 |
| esophagus | 94% | 2447.41 | 1362 / 1445 | 100% | 45.72 | 183 / 183 |
| kidney | 100% | 5644.45 | 89 / 89 | 94% | 23.27 | 844 / 901 |
| stomach | 91% | 1749.65 | 325 / 359 | 99% | 39.88 | 282 / 286 |
| uterus | 90% | 1854.65 | 153 / 170 | 99% | 38.47 | 455 / 459 |
| intestine | 89% | 2763.01 | 862 / 966 | 99% | 39.22 | 524 / 527 |
| pancreas | 90% | 1382.79 | 294 / 328 | 98% | 34.44 | 175 / 178 |
| adrenal gland | 100% | 5498.13 | 258 / 258 | 86% | 22.56 | 198 / 230 |
| prostate | 99% | 2608.87 | 243 / 245 | 86% | 10.53 | 431 / 502 |
| breast | 98% | 1571.43 | 449 / 459 | 87% | 15.51 | 970 / 1118 |
| skin | 85% | 1272.51 | 1539 / 1809 | 96% | 25.69 | 455 / 472 |
| bladder | 76% | 1559.33 | 16 / 21 | 98% | 35.80 | 494 / 504 |
| liver | 89% | 1531.77 | 202 / 226 | 67% | 10.31 | 272 / 406 |
| ovary | 52% | 706.93 | 93 / 180 | 99% | 43.73 | 426 / 430 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 61.45 | 29 / 29 |
| spleen | 100% | 5761.45 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 41.08 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 19.95 | 1 / 1 |
| blood vessel | 99% | 2269.75 | 1322 / 1335 | 0% | 0 | 0 / 0 |
| peripheral blood | 99% | 5506.43 | 919 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 99% | 28.65 | 79 / 80 |
| heart | 98% | 2537.49 | 845 / 861 | 0% | 0 | 0 / 0 |
| adipose | 97% | 1905.33 | 1172 / 1204 | 0% | 0 | 0 / 0 |
| muscle | 48% | 597.55 | 386 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0007602 | Biological process | phototransduction |
| GO_0015914 | Biological process | phospholipid transport |
| GO_0120009 | Biological process | intermembrane lipid transfer |
| GO_0007420 | Biological process | brain development |
| GO_0015031 | Biological process | protein transport |
| GO_0006629 | Biological process | lipid metabolic process |
| GO_0006661 | Biological process | phosphatidylinositol biosynthetic process |
| GO_0030496 | Cellular component | midbody |
| GO_0005811 | Cellular component | lipid droplet |
| GO_0016020 | Cellular component | membrane |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
| GO_0044297 | Cellular component | cell body |
| GO_0032154 | Cellular component | cleavage furrow |
| GO_0032580 | Cellular component | Golgi cisterna membrane |
| GO_0008526 | Molecular function | phosphatidylinositol transfer activity |
| GO_0008525 | Molecular function | phosphatidylcholine transporter activity |
| GO_0035091 | Molecular function | phosphatidylinositol binding |
| GO_0031210 | Molecular function | phosphatidylcholine binding |
| GO_0070300 | Molecular function | phosphatidic acid binding |
| GO_0005509 | Molecular function | calcium ion binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0030971 | Molecular function | receptor tyrosine kinase binding |
| Gene name | PITPNM1 |
| Protein name | Membrane-associated phosphatidylinositol transfer protein 1 (Drosophila retinal degeneration B homolog) (Phosphatidylinositol transfer protein, membrane-associated 1) (PITPnm 1) (Pyk2 N-terminal domain-interacting receptor 2) (NIR-2) Phosphatidylinositol transfer protein membrane associated 1 |
| Synonyms | NIR2 PITPNM DRES9 |
| Description | FUNCTION: Catalyzes the transfer of phosphatidylinositol (PI) between membranes . Binds PI, phosphatidylcholine (PC) and phosphatidic acid (PA) with the binding affinity order of PI > PA > PC . Regulates RHOA activity, and plays a role in cytoskeleton remodeling . Necessary for normal completion of cytokinesis . Plays a role in maintaining normal diacylglycerol levels in the Golgi apparatus . Necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus . Required for protein export from the endoplasmic reticulum and the Golgi . Binds calcium ions . . |
| Accessions | ENST00000524901.1 E9PSD1 O00562 ENST00000534749.5 [O00562-1] ENST00000532703.5 ENST00000436757.6 [O00562-2] E9PMS0 E9PMZ6 E9PNU6 ENST00000533391.5 ENST00000528559.5 ENST00000356404.8 [O00562-1] |
