PIP4P1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006644Biological processphospholipid metabolic process
GO_0008203Biological processcholesterol metabolic process
GO_0046856Biological processphosphatidylinositol dephosphorylation
GO_1904263Biological processpositive regulation of TORC1 signaling
GO_0006991Biological processresponse to sterol depletion
GO_0032418Biological processlysosome localization
GO_1901796Biological processregulation of signal transduction by p53 class mediator
GO_0070070Biological processproton-transporting V-type ATPase complex assembly
GO_0031902Cellular componentlate endosome membrane
GO_0005654Cellular componentnucleoplasm
GO_0005886Cellular componentplasma membrane
GO_0005765Cellular componentlysosomal membrane
GO_0030670Cellular componentphagocytic vesicle membrane
GO_0034597Molecular functionphosphatidylinositol-4,5-bisphosphate 4-phosphatase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePIP4P1
Protein nameType 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase (Type 1 PtdIns-4,5-P2 4-Ptase) (EC 3.1.3.78) (PtdIns-4,5-P2 4-Ptase I) (Transmembrane protein 55B)
Phosphatidylinositol-4,5-bisphosphate 4-phosphatase (EC 3.1.3.78)
SynonymsTMEM55B
C14orf9
DescriptionFUNCTION: Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) . Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate . Regulates lysosomal positioning by recruiting JIP4 to lysosomal membranes, thus inducing retrograde transport of lysosomes along microtubules . Contributes to assembly of the V-ATPase complex in lipid rafts of the lysosomal membrane and to subsequent amino acid-dependent activation of mTORC1 . May play a role in the regulation of cellular cholesterol metabolism . .

FUNCTION: Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). .

FUNCTION: Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P). .

AccessionsENST00000398020.6 [Q86T03-2]
ENST00000553460.5
ENST00000708818.1 [Q86T03-2]
Q86T03
ENST00000250489.9 [Q86T03-1]
H0YJ90
ENST00000708815.1 [Q86T03-1]
ENST00000556093.1
G3V5T5