PIP4K2C | OmnibusX

Name	Number of supported studies	Average coverage
GABAergic neuron	3 studies	21% ± 4%	Explore
glutamatergic neuron	3 studies	40% ± 10%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of PIP4K2C at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	2461.15	578 / 578	100%	80.04	1155 / 1155
ovary	100%	2123.09	180 / 180	100%	67.81	430 / 430
esophagus	100%	2792.30	1444 / 1445	100%	72.88	183 / 183
skin	100%	2714.07	1805 / 1809	100%	82.67	472 / 472
stomach	100%	3265.22	359 / 359	100%	55.27	285 / 286
uterus	100%	2593.38	170 / 170	99%	63.56	456 / 459
breast	100%	2436.46	457 / 459	100%	95.04	1115 / 1118
intestine	100%	2639.01	966 / 966	99%	58.49	523 / 527
prostate	100%	2621.60	245 / 245	99%	58.00	498 / 502
bladder	100%	2474.24	21 / 21	99%	63.21	499 / 504
kidney	100%	3976.96	89 / 89	99%	50.24	892 / 901
pancreas	100%	1611.55	327 / 328	99%	66.48	176 / 178
thymus	100%	2552.40	653 / 653	99%	53.86	596 / 605
adrenal gland	100%	2286.91	258 / 258	98%	54.96	225 / 230
brain	99%	2712.93	2617 / 2642	97%	59.18	687 / 705
liver	99%	1075.45	223 / 226	91%	29.22	369 / 406
spleen	100%	2033.54	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	69.08	45 / 45
ureter	0%	0	0 / 0	100%	46.36	1 / 1
blood vessel	100%	4269.54	1334 / 1335	0%	0	0 / 0
adipose	100%	1775.94	1203 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	99%	49.76	79 / 80
heart	97%	1263.15	831 / 861	0%	0	0 / 0
muscle	96%	1088.38	770 / 803	0%	0	0 / 0
peripheral blood	92%	1426.52	855 / 929	0%	0	0 / 0
lymph node	0%	0	0 / 0	86%	26.70	25 / 29
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_1902635	Biological process	1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process
GO_2000786	Biological process	positive regulation of autophagosome assembly
GO_0046854	Biological process	phosphatidylinositol phosphate biosynthetic process
GO_0010506	Biological process	regulation of autophagy
GO_0046627	Biological process	negative regulation of insulin receptor signaling pathway
GO_0043229	Cellular component	intracellular organelle
GO_0070062	Cellular component	extracellular exosome
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005886	Cellular component	plasma membrane
GO_0005776	Cellular component	autophagosome
GO_0042802	Molecular function	identical protein binding
GO_0005515	Molecular function	protein binding
GO_0016308	Molecular function	1-phosphatidylinositol-4-phosphate 5-kinase activity
GO_0005524	Molecular function	ATP binding
GO_0016309	Molecular function	1-phosphatidylinositol-5-phosphate 4-kinase activity

Gene name	PIP4K2C
Protein name	Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (EC 2.7.1.149) (Phosphatidylinositol 5-phosphate 4-kinase type II gamma) Phosphatidylinositol-5-phosphate 4-kinase type 2 gamma Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (EC 2.7.1.149) (Phosphatidylinositol 5-phosphate 4-kinase type II gamma) (PI(5)P 4-kinase type II gamma) (PIP4KII-gamma)
Synonyms	PIP5K2C
Description	FUNCTION: Phosphatidylinositol 5-phosphate 4-kinase with low enzymatic activity. May be a GTP sensor, has higher GTP-dependent kinase activity than ATP-dependent kinase activity. PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 . .
Accessions	Q8TBX8 ENST00000550465.5 [Q8TBX8-3] ENST00000548264.1 F8VNT5 ENST00000540759.6 [Q8TBX8-1] H0YIJ6 ENST00000550095.5 ENST00000551772.5 F8VVB2 ENST00000550360.1 F8VU68 ENST00000354947.10 [Q8TBX8-1] ENST00000422156.7 [Q8TBX8-2]

PIP4K2C report