PIP4K2B | OmnibusX

Name	Number of supported studies	Average coverage
brain	6 studies	25% ± 11%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
bladder	100%	6490.24	21 / 21	100%	40.01	504 / 504
brain	100%	15552.99	2642 / 2642	100%	143.39	705 / 705
breast	100%	5970.98	459 / 459	100%	72.16	1118 / 1118
prostate	100%	6678.71	245 / 245	100%	51.65	502 / 502
thymus	100%	6233.43	653 / 653	100%	58.05	604 / 605
uterus	100%	9197.18	170 / 170	100%	46.28	458 / 459
skin	100%	5037.89	1803 / 1809	100%	73.50	472 / 472
intestine	100%	5697.46	964 / 966	99%	31.94	524 / 527
esophagus	100%	5427.70	1441 / 1445	99%	47.03	182 / 183
ovary	100%	9709.82	180 / 180	99%	39.50	426 / 430
lung	99%	5258.67	574 / 578	100%	43.95	1152 / 1155
adrenal gland	100%	7353.79	257 / 258	98%	54.75	226 / 230
kidney	100%	4795.91	89 / 89	98%	50.71	881 / 901
stomach	97%	3825.25	348 / 359	99%	34.64	284 / 286
pancreas	94%	2532.64	308 / 328	99%	41.63	176 / 178
liver	88%	1983.67	199 / 226	93%	23.95	376 / 406
adipose	100%	5639.73	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	54.66	80 / 80
lymph node	0%	0	0 / 0	100%	35.90	29 / 29
muscle	100%	9413.83	803 / 803	0%	0	0 / 0
spleen	100%	6598.54	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	35.37	45 / 45
ureter	0%	0	0 / 0	100%	31.45	1 / 1
blood vessel	100%	6707.15	1334 / 1335	0%	0	0 / 0
heart	98%	4322.74	845 / 861	0%	0	0 / 0
peripheral blood	59%	2046.97	551 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_2000786	Biological process	positive regulation of autophagosome assembly
GO_0061909	Biological process	autophagosome-lysosome fusion
GO_1902635	Biological process	1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process
GO_0046854	Biological process	phosphatidylinositol phosphate biosynthetic process
GO_0046627	Biological process	negative regulation of insulin receptor signaling pathway
GO_0010506	Biological process	regulation of autophagy
GO_0007166	Biological process	cell surface receptor signaling pathway
GO_0005886	Cellular component	plasma membrane
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005776	Cellular component	autophagosome
GO_0005634	Cellular component	nucleus
GO_0042803	Molecular function	protein homodimerization activity
GO_0016308	Molecular function	1-phosphatidylinositol-4-phosphate 5-kinase activity
GO_0016309	Molecular function	1-phosphatidylinositol-5-phosphate 4-kinase activity
GO_0005525	Molecular function	GTP binding
GO_0005524	Molecular function	ATP binding
GO_0005515	Molecular function	protein binding

Gene name	PIP4K2B
Protein name	Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-beta) (Diphosphoinositide kinase 2-beta) (Phosphatidylinositol 5-phosphate 4-kinase type II beta) (PI(5)P 4-kinase type II beta) (PIP4KII-beta) (PtdIns(5)P-4-kinase isoform 2-beta)
Synonyms	PIP5K2B
Description	FUNCTION: Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate . Preferentially utilizes GTP, rather than ATP, for PI(5)P phosphorylation and its activity reflects changes in direct proportion to the physiological GTP concentration . Its GTP-sensing activity is critical for metabolic adaptation . PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 . .
Accessions	P78356 ENST00000631946.1 ENST00000613180.2 [P78356-1] ENST00000619039.5 [P78356-1] A0A087WT35 ENST00000617499.1

PIP4K2B report