PINX1 | OmnibusX

Name	Number of supported studies	Average coverage
astrocyte	3 studies	20% ± 5%	Explore

Name	Number of supported studies	Average coverage
brain	3 studies	24% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	100%	532.57	653 / 653	100%	7.77	603 / 605
skin	100%	782.29	1809 / 1809	100%	16.10	470 / 472
brain	100%	386.33	2629 / 2642	100%	7.54	705 / 705
esophagus	100%	588.36	1445 / 1445	99%	8.47	182 / 183
uterus	100%	625.58	170 / 170	99%	9.53	456 / 459
stomach	100%	396.30	359 / 359	99%	8.04	283 / 286
bladder	100%	602.10	21 / 21	99%	7.39	497 / 504
intestine	100%	510.94	966 / 966	98%	8.15	519 / 527
lung	100%	504.34	577 / 578	99%	6.10	1138 / 1155
pancreas	100%	311.61	328 / 328	98%	6.06	175 / 178
prostate	100%	511.42	245 / 245	98%	5.40	493 / 502
kidney	100%	471.18	89 / 89	97%	4.94	872 / 901
ovary	100%	558.87	180 / 180	97%	5.19	415 / 430
breast	100%	612.88	459 / 459	96%	5.42	1075 / 1118
adrenal gland	100%	437.00	258 / 258	95%	5.25	219 / 230
liver	100%	380.38	226 / 226	94%	4.56	382 / 406
adipose	100%	589.58	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	13.17	80 / 80
lymph node	0%	0	0 / 0	100%	20.28	29 / 29
spleen	100%	550.05	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	9.90	45 / 45
ureter	0%	0	0 / 0	100%	3.10	1 / 1
blood vessel	100%	505.23	1334 / 1335	0%	0	0 / 0
muscle	100%	470.26	801 / 803	0%	0	0 / 0
heart	98%	322.71	847 / 861	0%	0	0 / 0
peripheral blood	87%	422.81	812 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0008285	Biological process	negative regulation of cell population proliferation
GO_1902570	Biological process	protein localization to nucleolus
GO_0051974	Biological process	negative regulation of telomerase activity
GO_0051972	Biological process	regulation of telomerase activity
GO_1904357	Biological process	negative regulation of telomere maintenance via telomere lengthening
GO_1904744	Biological process	positive regulation of telomeric DNA binding
GO_0032211	Biological process	negative regulation of telomere maintenance via telomerase
GO_0070198	Biological process	protein localization to chromosome, telomeric region
GO_0007080	Biological process	mitotic metaphase chromosome alignment
GO_1904751	Biological process	positive regulation of protein localization to nucleolus
GO_0031647	Biological process	regulation of protein stability
GO_0007004	Biological process	telomere maintenance via telomerase
GO_0031397	Biological process	negative regulation of protein ubiquitination
GO_0005730	Cellular component	nucleolus
GO_0005739	Cellular component	mitochondrion
GO_0000228	Cellular component	nuclear chromosome
GO_0000776	Cellular component	kinetochore
GO_0005654	Cellular component	nucleoplasm
GO_0005819	Cellular component	spindle
GO_0000781	Cellular component	chromosome, telomeric region
GO_0044877	Molecular function	protein-containing complex binding
GO_0010521	Molecular function	telomerase inhibitor activity
GO_0070034	Molecular function	telomerase RNA binding
GO_0005515	Molecular function	protein binding

Gene name	PINX1
Protein name	PIN2 (TERF1) interacting telomerase inhibitor 1 PIN2/TERF1-interacting telomerase inhibitor 1 (Liver-related putative tumor suppressor) (Pin2-interacting protein X1) (Protein 67-11-3) (TRF1-interacting protein 1)
Synonyms	LPTL LPTS
Description	FUNCTION: Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor. .
Accessions	ENST00000710827.1 [Q96BK5-2] E5RJG9 H0YBF0 ENST00000519088.5 [Q96BK5-2] ENST00000647329.2 [Q96BK5-1] E5RGR1 ENST00000524061.1 ENST00000524114.6 Q96BK5 ENST00000523559.1 ENST00000314787.8 [Q96BK5-1]

PINX1 report