I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| GABAergic neuron | 3 studies | 38% ± 3% | |
| glutamatergic neuron | 3 studies | 48% ± 4% | |
| astrocyte | 3 studies | 25% ± 6% | |
| oligodendrocyte | 3 studies | 23% ± 5% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| GABAergic neuron | 3 studies | 38% ± 3% | |
| glutamatergic neuron | 3 studies | 48% ± 4% | |
| astrocyte | 3 studies | 25% ± 6% | |
| oligodendrocyte | 3 studies | 23% ± 5% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 4 studies | 34% ± 8% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 1788.10 | 1444 / 1445 | 100% | 33.18 | 183 / 183 |
| lung | 100% | 2031.95 | 578 / 578 | 100% | 26.60 | 1154 / 1155 |
| breast | 100% | 2263.38 | 459 / 459 | 100% | 33.31 | 1116 / 1118 |
| ovary | 100% | 2098.78 | 180 / 180 | 100% | 19.82 | 429 / 430 |
| stomach | 100% | 1516.72 | 359 / 359 | 99% | 20.07 | 284 / 286 |
| prostate | 100% | 1712.44 | 245 / 245 | 99% | 26.64 | 497 / 502 |
| intestine | 100% | 1893.87 | 966 / 966 | 99% | 18.69 | 521 / 527 |
| thymus | 100% | 2430.12 | 653 / 653 | 99% | 28.04 | 598 / 605 |
| uterus | 100% | 2333.04 | 170 / 170 | 99% | 27.14 | 453 / 459 |
| bladder | 100% | 1967.43 | 21 / 21 | 99% | 20.67 | 497 / 504 |
| brain | 99% | 1255.18 | 2609 / 2642 | 100% | 24.19 | 703 / 705 |
| pancreas | 99% | 981.70 | 326 / 328 | 99% | 19.07 | 176 / 178 |
| skin | 100% | 2368.50 | 1809 / 1809 | 98% | 30.43 | 463 / 472 |
| kidney | 100% | 1254.82 | 89 / 89 | 97% | 20.35 | 877 / 901 |
| adrenal gland | 100% | 2024.71 | 258 / 258 | 94% | 16.29 | 216 / 230 |
| liver | 100% | 1409.16 | 226 / 226 | 93% | 13.74 | 376 / 406 |
| adipose | 100% | 2159.21 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 2009.73 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| spleen | 100% | 1959.66 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 39.50 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 8.82 | 1 / 1 |
| muscle | 100% | 1177.18 | 801 / 803 | 0% | 0 | 0 / 0 |
| heart | 97% | 1085.40 | 833 / 861 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 97% | 16.88 | 28 / 29 |
| eye | 0% | 0 | 0 / 0 | 95% | 17.05 | 76 / 80 |
| peripheral blood | 81% | 933.44 | 752 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0042149 | Biological process | cellular response to glucose starvation |
| GO_0006623 | Biological process | protein targeting to vacuole |
| GO_0030242 | Biological process | autophagy of peroxisome |
| GO_0006622 | Biological process | protein targeting to lysosome |
| GO_0045324 | Biological process | late endosome to vacuole transport |
| GO_0016236 | Biological process | macroautophagy |
| GO_0036092 | Biological process | phosphatidylinositol-3-phosphate biosynthetic process |
| GO_0010506 | Biological process | regulation of autophagy |
| GO_0043491 | Biological process | phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| GO_0016241 | Biological process | regulation of macroautophagy |
| GO_0006468 | Biological process | protein phosphorylation |
| GO_0045022 | Biological process | early endosome to late endosome transport |
| GO_0097352 | Biological process | autophagosome maturation |
| GO_0032801 | Biological process | receptor catabolic process |
| GO_0032465 | Biological process | regulation of cytokinesis |
| GO_0071561 | Cellular component | nucleus-vacuole junction |
| GO_0016020 | Cellular component | membrane |
| GO_0035032 | Cellular component | phosphatidylinositol 3-kinase complex, class III |
| GO_0005930 | Cellular component | axoneme |
| GO_0005829 | Cellular component | cytosol |
| GO_0015630 | Cellular component | microtubule cytoskeleton |
| GO_0034271 | Cellular component | phosphatidylinositol 3-kinase complex, class III, type I |
| GO_0034272 | Cellular component | phosphatidylinositol 3-kinase complex, class III, type II |
| GO_0005770 | Cellular component | late endosome |
| GO_0005776 | Cellular component | autophagosome |
| GO_0030670 | Cellular component | phagocytic vesicle membrane |
| GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
| GO_0106310 | Molecular function | protein serine kinase activity |
| GO_0004674 | Molecular function | protein serine/threonine kinase activity |
| GO_0004672 | Molecular function | protein kinase activity |
| GO_0005524 | Molecular function | ATP binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | PIK3R4 |
| Protein name | non-specific serine/threonine protein kinase (EC 2.7.11.1) Phosphoinositide-3-kinase regulatory subunit 4 Phosphoinositide 3-kinase regulatory subunit 4 (PI3-kinase regulatory subunit 4) (EC 2.7.11.1) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein) |
| Synonyms | VPS15 |
| Description | FUNCTION: Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 . . |
| Accessions | ENST00000356763.8 ENST00000508273.5 A0JP11 ENST00000507330.5 D6RAC3 D6RJ98 D6RBB7 Q99570 ENST00000512430.1 |
