PIK3C3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042149Biological processcellular response to glucose starvation
GO_0006897Biological processendocytosis
GO_0030242Biological processautophagy of peroxisome
GO_0006622Biological processprotein targeting to lysosome
GO_0000045Biological processautophagosome assembly
GO_0006497Biological processprotein lipidation
GO_0034497Biological processprotein localization to phagophore assembly site
GO_0044829Biological processpositive regulation by host of viral genome replication
GO_0016236Biological processmacroautophagy
GO_0046854Biological processphosphatidylinositol phosphate biosynthetic process
GO_0051301Biological processcell division
GO_0048015Biological processphosphatidylinositol-mediated signaling
GO_0036092Biological processphosphatidylinositol-3-phosphate biosynthetic process
GO_0010506Biological processregulation of autophagy
GO_0006914Biological processautophagy
GO_0016241Biological processregulation of macroautophagy
GO_0045022Biological processearly endosome to late endosome transport
GO_0097352Biological processautophagosome maturation
GO_0032465Biological processregulation of cytokinesis
GO_0030496Cellular componentmidbody
GO_0016020Cellular componentmembrane
GO_0044754Cellular componentautolysosome
GO_0035032Cellular componentphosphatidylinositol 3-kinase complex, class III
GO_0005777Cellular componentperoxisome
GO_0005930Cellular componentaxoneme
GO_0005829Cellular componentcytosol
GO_0034272Cellular componentphosphatidylinositol 3-kinase complex, class III, type II
GO_0034271Cellular componentphosphatidylinositol 3-kinase complex, class III, type I
GO_0005776Cellular componentautophagosome
GO_0000407Cellular componentphagophore assembly site
GO_0005737Cellular componentcytoplasm
GO_0005770Cellular componentlate endosome
GO_0030670Cellular componentphagocytic vesicle membrane
GO_0005768Cellular componentendosome
GO_0052742Molecular functionphosphatidylinositol kinase activity
GO_0004672Molecular functionprotein kinase activity
GO_0005524Molecular functionATP binding
GO_0016301Molecular functionkinase activity
GO_0016303Molecular function1-phosphatidylinositol-3-kinase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePIK3C3
Protein namePhosphatidylinositol 3-kinase catalytic subunit type 3 (EC 2.7.1.137)
Phosphatidylinositol 3-kinase catalytic subunit type 3 (PI3-kinase type 3) (PI3K type 3) (PtdIns-3-kinase type 3) (EC 2.7.1.137) (Phosphatidylinositol 3-kinase p100 subunit) (Phosphoinositide-3-kinase class 3) (hVps34)
Phosphatidylinositol 3-kinase catalytic subunit type 3
phosphatidylinositol 3-kinase (EC 2.7.1.137)
SynonymsVPS34
DescriptionFUNCTION: Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis . As part of PI3KC3-C1, promotes endoplasmic reticulum membrane curvature formation prior to vesicle budding . Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 . Involved in the transport of lysosomal enzyme precursors to lysosomes (By similarity). Required for transport from early to late endosomes (By similarity). .; FUNCTION: (Microbial infection) Kinase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. .

AccessionsK7EKH3
ENST00000398870.7
ENST00000597477.5
A0A0B4J2B1
ENST00000586545.5
M0R386
K7ENH3
ENST00000587402.2
A8MYT4
M0R308
ENST00000585528.5
ENST00000589056.5
ENST00000262039.9
K7EIV6
ENST00000591011.1
Q8NEB9