PI4K2A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0046854Biological processphosphatidylinositol phosphate biosynthetic process
GO_0007030Biological processGolgi organization
GO_0007032Biological processendosome organization
GO_0006661Biological processphosphatidylinositol biosynthetic process
GO_0005886Cellular componentplasma membrane
GO_0045121Cellular componentmembrane raft
GO_0031410Cellular componentcytoplasmic vesicle
GO_0016020Cellular componentmembrane
GO_0005739Cellular componentmitochondrion
GO_0043204Cellular componentperikaryon
GO_0031901Cellular componentearly endosome membrane
GO_0043025Cellular componentneuronal cell body
GO_0043005Cellular componentneuron projection
GO_0035838Cellular componentgrowing cell tip
GO_0042734Cellular componentpresynaptic membrane
GO_0030425Cellular componentdendrite
GO_0005802Cellular componenttrans-Golgi network
GO_0000139Cellular componentGolgi membrane
GO_0005829Cellular componentcytosol
GO_0031083Cellular componentBLOC-1 complex
GO_0005768Cellular componentendosome
GO_0005765Cellular componentlysosomal membrane
GO_0035651Molecular functionAP-3 adaptor complex binding
GO_0000287Molecular functionmagnesium ion binding
GO_0005524Molecular functionATP binding
GO_0004430Molecular function1-phosphatidylinositol 4-kinase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePI4K2A
Protein namePhosphatidylinositol 4-kinase type 2-alpha (EC 2.7.1.67) (Phosphatidylinositol 4-kinase type II-alpha)
Synonyms
DescriptionFUNCTION: Membrane-bound phosphatidylinositol-4 kinase (PI4-kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking and is required for prolonged survival of neurons. Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). .

AccessionsENST00000370631.4
Q9BTU6