Insufficient scRNA-seq data for expression of PHOX2B at tissue level.
Tissue | GTEx Coverage  | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| adrenal gland | 38% | 210.96 | 98 / 258 | 65% | 130.65 | 149 / 230 |
| intestine | 91% | 237.68 | 881 / 966 | 1% | 0.02 | 6 / 527 |
| esophagus | 35% | 26.28 | 506 / 1445 | 0% | 0 | 0 / 183 |
| stomach | 32% | 39.58 | 115 / 359 | 3% | 0.05 | 8 / 286 |
| pancreas | 1% | 0.26 | 3 / 328 | 4% | 0.12 | 8 / 178 |
| prostate | 4% | 3.37 | 9 / 245 | 1% | 0.02 | 4 / 502 |
| lymph node | 0% | 0 | 0 / 0 | 3% | 0.06 | 1 / 29 |
| lung | 0% | 0 | 0 / 578 | 3% | 0.38 | 36 / 1155 |
| bladder | 0% | 0 | 0 / 21 | 2% | 0.15 | 10 / 504 |
| brain | 1% | 0.71 | 19 / 2642 | 1% | 0.02 | 7 / 705 |
| heart | 2% | 0.75 | 14 / 861 | 0% | 0 | 0 / 0 |
| uterus | 0% | 0 | 0 / 170 | 1% | 0.08 | 4 / 459 |
| breast | 0% | 0.14 | 1 / 459 | 0% | 0.00 | 3 / 1118 |
| kidney | 0% | 0 | 0 / 89 | 0% | 0.01 | 3 / 901 |
| adipose | 0% | 0.13 | 3 / 1204 | 0% | 0 | 0 / 0 |
| muscle | 0% | 0.09 | 2 / 803 | 0% | 0 | 0 / 0 |
| liver | 0% | 0 | 0 / 226 | 0% | 0.00 | 1 / 406 |
| blood vessel | 0% | 0.06 | 3 / 1335 | 0% | 0 | 0 / 0 |
| skin | 0% | 0 | 0 / 1809 | 0% | 0.01 | 1 / 472 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ovary | 0% | 0 | 0 / 180 | 0% | 0 | 0 / 430 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
| thymus | 0% | 0 | 0 / 653 | 0% | 0 | 0 / 605 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_1901166 | Biological process | neural crest cell migration involved in autonomic nervous system development |
| GO_0010468 | Biological process | regulation of gene expression |
| GO_0002087 | Biological process | regulation of respiratory gaseous exchange by nervous system process |
| GO_0051899 | Biological process | membrane depolarization |
| GO_0010971 | Biological process | positive regulation of G2/M transition of mitotic cell cycle |
| GO_0071773 | Biological process | cellular response to BMP stimulus |
| GO_0048485 | Biological process | sympathetic nervous system development |
| GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
| GO_0010001 | Biological process | glial cell differentiation |
| GO_1904691 | Biological process | negative regulation of type B pancreatic cell proliferation |
| GO_0071244 | Biological process | cellular response to carbon dioxide |
| GO_0001764 | Biological process | neuron migration |
| GO_0048839 | Biological process | inner ear development |
| GO_0003357 | Biological process | noradrenergic neuron differentiation |
| GO_0061452 | Biological process | retrotrapezoid nucleus neuron differentiation |
| GO_0014823 | Biological process | response to activity |
| GO_0048486 | Biological process | parasympathetic nervous system development |
| GO_0071542 | Biological process | dopaminergic neuron differentiation |
| GO_0097475 | Biological process | motor neuron migration |
| GO_0061549 | Biological process | sympathetic ganglion development |
| GO_0021934 | Biological process | hindbrain tangential cell migration |
| GO_0060541 | Biological process | respiratory system development |
| GO_0021533 | Biological process | cell differentiation in hindbrain |
| GO_0045665 | Biological process | negative regulation of neuron differentiation |
| GO_0003360 | Biological process | brainstem development |
| GO_0021723 | Biological process | medullary reticular formation development |
| GO_0120162 | Biological process | positive regulation of cold-induced thermogenesis |
| GO_0048894 | Biological process | efferent axon development in a lateral line nerve |
| GO_0048483 | Biological process | autonomic nervous system development |
| GO_0035914 | Biological process | skeletal muscle cell differentiation |
| GO_0045666 | Biological process | positive regulation of neuron differentiation |
| GO_0003358 | Biological process | noradrenergic neuron development |
| GO_0044342 | Biological process | type B pancreatic cell proliferation |
| GO_0048484 | Biological process | enteric nervous system development |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0000785 | Cellular component | chromatin |
| GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO_0001228 | Molecular function | DNA-binding transcription activator activity, RNA polymerase II-specific |
| GO_0000977 | Molecular function | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO_1990837 | Molecular function | sequence-specific double-stranded DNA binding |
| Gene name | PHOX2B |
| Protein name | Paired like homeobox2B Paired like homeobox 2B Paired mesoderm homeobox protein 2B (Neuroblastoma Phox) (NBPhox) (PHOX2B homeodomain protein) (Paired-like homeobox 2B) |
| Synonyms | PMX2B |
| Description | FUNCTION: Involved in the development of several major noradrenergic neuron populations, including the locus coeruleus. Transcription factor which could determine a neurotransmitter phenotype in vertebrates. Enhances second-messenger-mediated activation of the dopamine beta-hydrolase and c-fos promoters, and of several enhancers including cAMP-response element and serum-response element. |
| Accessions | Q99453 ENST00000226382.4 A0A5A4PVW8 A0A455R6J4 |
