PHOX2A report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PHOX2A at tissue level.

III. Associated gene sets

GO_0048485Biological processsympathetic nervous system development
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0021523Biological processsomatic motor neuron differentiation
GO_0003357Biological processnoradrenergic neuron differentiation
GO_0043576Biological processregulation of respiratory gaseous exchange
GO_0071542Biological processdopaminergic neuron differentiation
GO_0021703Biological processlocus ceruleus development
GO_0021623Biological processoculomotor nerve formation
GO_0021642Biological processtrochlear nerve formation
GO_0030901Biological processmidbrain development
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0000977Molecular functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePHOX2A
Protein namePaired like homeobox 2A
Phox2a protein
Paired mesoderm homeobox protein 2A (ARIX1 homeodomain protein) (Aristaless homeobox protein homolog) (Paired-like homeobox 2A)
SynonymsARIX
PMX2A
DescriptionFUNCTION: May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. Acts as a transcription activator/factor. Could maintain the noradrenergic phenotype.

AccessionsENST00000546310.1
H0YGU5
ENST00000298231.5
Q96KQ2
O14813