PHF8 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0061188Biological processnegative regulation of rDNA heterochromatin formation
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0006482Biological processprotein demethylation
GO_0006338Biological processchromatin remodeling
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0045943Biological processpositive regulation of transcription by RNA polymerase I
GO_0007420Biological processbrain development
GO_0000082Biological processG1/S transition of mitotic cell cycle
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0031965Cellular componentnuclear membrane
GO_0005634Cellular componentnucleus
GO_0035064Molecular functionmethylated histone binding
GO_0032454Molecular functionhistone H3K9 demethylase activity
GO_0003682Molecular functionchromatin binding
GO_0016706Molecular function2-oxoglutarate-dependent dioxygenase activity
GO_0140683Molecular functionhistone H3K9me/H3K9me2 demethylase activity
GO_0003712Molecular functiontranscription coregulator activity
GO_0051864Molecular functionhistone H3K36 demethylase activity
GO_0032452Molecular functionhistone demethylase activity
GO_0005506Molecular functioniron ion binding
GO_0008270Molecular functionzinc ion binding
GO_0035575Molecular functionhistone H4K20 demethylase activity
GO_0071558Molecular functionhistone H3K27me2/H3K27me3 demethylase activity
GO_0005515Molecular functionprotein binding
GO_0140680Molecular functionhistone H3K36me/H3K36me2 demethylase activity

IV. Literature review

[source]
Gene namePHF8
Protein nameHistone lysine demethylase PHF8 (EC 1.14.11.27) (EC 1.14.11.65) (PHD finger protein 8) ([histone H3]-dimethyl-L-lysine(36) demethylase PHF8) ([histone H3]-dimethyl-L-lysine(9) demethylase PHF8)
PHD finger protein 8
SynonymsZNF422
KIAA1111
DescriptionFUNCTION: Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role cell cycle progression, rDNA transcription and brain development. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2), dimethylated H3 'Lys-27' (H3K27Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivator of rDNA transcription, by activating polymerase I (pol I) mediated transcription of rRNA genes. Required for brain development, probably by regulating expression of neuron-specific genes. Only has activity toward H4K20Me1 when nucleosome is used as a substrate and when not histone octamer is used as substrate. May also have weak activity toward dimethylated H3 'Lys-36' (H3K36Me2), however, the relevance of this result remains unsure in vivo. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: has weak activity toward H3K9Me2 in absence of H3K4me3, while it has high activity toward H3K9me2 when binding H3K4me3. Positively modulates transcription of histone demethylase KDM5C, acting synergistically with transcription factor ARX; synergy may be related to enrichment of histone H3K4me3 in regulatory elements. .

AccessionsENST00000453905.5
H0Y7M8
ENST00000396282.7
ENST00000433120.5
H0Y589
B0QZZ3
ENST00000357988.9 [Q9UPP1-1]
H0Y3N9
A0A8J8YW94
B0QZZ2
ENST00000443302.5
ENST00000448003.1
Q5JPR8
Q9UPP1
ENST00000338946.11
B0QZZ4
ENST00000445025.1
ENST00000687764.1
ENST00000415025.5
B0QZE1
ENST00000425862.5
A0A8I5KT77
A0A8I5KVK1
ENST00000437224.5
ENST00000322659.12 [Q9UPP1-5]
ENST00000338154.11 [Q9UPP1-2]
ENST00000686349.1