PHF10 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030071Biological processregulation of mitotic metaphase/anaphase transition
GO_0045582Biological processpositive regulation of T cell differentiation
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_2000045Biological processregulation of G1/S transition of mitotic cell cycle
GO_0045663Biological processpositive regulation of myoblast differentiation
GO_0006338Biological processchromatin remodeling
GO_0070316Biological processregulation of G0 to G1 transition
GO_1902459Biological processpositive regulation of stem cell population maintenance
GO_0045597Biological processpositive regulation of cell differentiation
GO_2000819Biological processregulation of nucleotide-excision repair
GO_2000781Biological processpositive regulation of double-strand break repair
GO_0007399Biological processnervous system development
GO_0071564Cellular componentnpBAF complex
GO_0000776Cellular componentkinetochore
GO_0016514Cellular componentSWI/SNF complex
GO_0005654Cellular componentnucleoplasm
GO_0016363Cellular componentnuclear matrix
GO_0016586Cellular componentRSC-type complex
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0003682Molecular functionchromatin binding
GO_0003712Molecular functiontranscription coregulator activity
GO_0046872Molecular functionmetal ion binding
GO_0004402Molecular functionhistone acetyltransferase activity

IV. Literature review

[source]
Gene namePHF10
Protein namePHD finger protein 10 (PHF10 isoform Sl)
PHD finger protein 10 (BRG1-associated factor 45a) (BAF45a) (XAP135)
SynonymsBAF45A
DescriptionFUNCTION: Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). .

AccessionsS5FZ81
Q8WUB8
ENST00000366780.8 [Q8WUB8-2]
ENST00000621772.4 [Q8WUB8-3]
ENST00000612128.1
ENST00000339209.9 [Q8WUB8-1]