PELP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071391Biological processcellular response to estrogen stimulus
GO_0006364Biological processrRNA processing
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005730Cellular componentnucleolus
GO_0000791Cellular componenteuchromatin
GO_0005654Cellular componentnucleoplasm
GO_0071339Cellular componentMLL1 complex
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0032183Molecular functionSUMO binding
GO_0005515Molecular functionprotein binding
GO_0003682Molecular functionchromatin binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene namePELP1
Protein nameProline-, glutamic acid- and leucine-rich protein 1 (Modulator of non-genomic activity of estrogen receptor)
Proline, glutamate and leucine rich protein 1
Proline-, glutamic acid- and leucine-rich protein 1 (Modulator of non-genomic activity of estrogen receptor) (Transcription factor HMX3)
SynonymsHMX3
MNAR
DescriptionFUNCTION: Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors . Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Functions as the key stabilizing component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit. Regulates pre-60S association of the critical remodeling factor MDN1 . May promote tumorigenesis via its interaction with and modulation of several oncogenes including SRC, PI3K, STAT3 and EGFR. Plays a role in cancer cell metastasis via its ability to modulate E2-mediated cytoskeleton changes and cell migration via its interaction with SRC and PI3K. .

AccessionsI3L4P1
ENST00000575101.1
I3L1P4
ENST00000575329.5
Q8IZL8
I3L445
E7EV54
I3L4M7
ENST00000572293.7
ENST00000574876.5
C9JFV4
ENST00000436683.6
ENST00000570387.5
ENST00000570571.5
ENST00000301396.8