PELI3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PELI3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PELI3 at tissue level.

III. Associated gene sets

GO_0008592Biological processregulation of Toll signaling pathway
GO_0010804Biological processnegative regulation of tumor necrosis factor-mediated signaling pathway
GO_0070534Biological processprotein K63-linked ubiquitination
GO_0045087Biological processinnate immune response
GO_2001237Biological processnegative regulation of extrinsic apoptotic signaling pathway
GO_0005829Cellular componentcytosol
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePELI3
Protein namePellino E3 ubiquitin protein ligase family member 3
E3 ubiquitin-protein ligase pellino homolog 3 (Pellino-3) (EC 2.3.2.27)
PELI3 protein
Synonyms
DescriptionFUNCTION: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins . Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6 . Mediates 'Lys-63'-linked polyubiquitination of IRAK1 . Can activate AP1/JUN and ELK1 . Acts as a regulator of innate immunity by mediating 'Lys-63'-linked polyubiquitination of RIPK2 downstream of NOD1 and NOD2, thereby transforming RIPK2 into a scaffolding protein for downstream effectors, ultimately leading to activation of the NF-kappa-B and MAP kinases signaling (By similarity). Catalyzes 'Lys-63'-linked polyubiquitination of RIPK2 in parallel of XIAP (By similarity). .

AccessionsENST00000532970.5
ENST00000527230.2
A1L176
ENST00000618547.4 [Q8N2H9-3]
E9PR85
ENST00000349459.10 [Q8N2H9-2]
Q8N2H9
E9PQX6
ENST00000524466.5 [Q8N2H9-4]
H0YEM6
ENST00000528752.1
ENST00000320740.12 [Q8N2H9-1]
ENST00000526296.5
E9PI91