PDZK1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0044070Biological processregulation of monoatomic anion transport
GO_0072659Biological processprotein localization to plasma membrane
GO_1990961Biological processxenobiotic detoxification by transmembrane export across the plasma membrane
GO_1905477Biological processpositive regulation of protein localization to membrane
GO_0090314Biological processpositive regulation of protein targeting to membrane
GO_0032414Biological processpositive regulation of ion transmembrane transporter activity
GO_1904064Biological processpositive regulation of cation transmembrane transport
GO_0015879Biological processcarnitine transport
GO_0031526Cellular componentbrush border membrane
GO_0005903Cellular componentbrush border
GO_0016324Cellular componentapical plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0031528Cellular componentmicrovillus membrane
GO_0070062Cellular componentextracellular exosome
GO_0043495Molecular functionprotein-membrane adaptor activity
GO_0044877Molecular functionprotein-containing complex binding
GO_0005102Molecular functionsignaling receptor binding
GO_0030165Molecular functionPDZ domain binding
GO_0005124Molecular functionscavenger receptor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePDZK1
Protein nameNa(+)/H(+) exchange regulatory cofactor NHE-RF3 (NHERF-3) (CFTR-associated protein of 70 kDa) (Na(+)/H(+) exchanger regulatory factor 3) (Na/Pi cotransporter C-terminal-associated protein 1) (NaPi-Cap1) (PDZ domain-containing protein 1) (Sodium-hydrogen exchanger regulatory factor 3)
PDZ domain containing 1
SynonymsNHERF3
CAP70
PDZD1
DescriptionFUNCTION: A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with NHERF1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function (By similarity). .

AccessionsENST00000417171.6 [Q5T2W1-1]
ENST00000344770.6 [Q5T2W1-1]
ENST00000443667.1
A0A0C4DG67
Q5T2W1
ENST00000451928.6 [Q5T2W1-2]