PDK3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0035357Biological processperoxisome proliferator activated receptor signaling pathway
GO_0071398Biological processcellular response to fatty acid
GO_0018105Biological processpeptidyl-serine phosphorylation
GO_2000377Biological processregulation of reactive oxygen species metabolic process
GO_0006468Biological processprotein phosphorylation
GO_0010906Biological processregulation of glucose metabolic process
GO_0097411Biological processhypoxia-inducible factor-1alpha signaling pathway
GO_0010510Biological processregulation of acetyl-CoA biosynthetic process from pyruvate
GO_0005730Cellular componentnucleolus
GO_0005759Cellular componentmitochondrial matrix
GO_0005739Cellular componentmitochondrion
GO_0004740Molecular functionpyruvate dehydrogenase (acetyl-transferring) kinase activity
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0005515Molecular functionprotein binding
GO_0004672Molecular functionprotein kinase activity
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene namePDK3
Protein name[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 3)
SynonymsPDHK3
DescriptionFUNCTION: Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation. Plays a role in the generation of reactive oxygen species. .

AccessionsENST00000648777.1 [Q15120-1]
ENST00000379162.9 [Q15120-1]
Q15120
ENST00000568479.2 [Q15120-2]