PDK2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PDK2 at tissue level.

III. Associated gene sets

GO_0034614Biological processcellular response to reactive oxygen species
GO_0010906Biological processregulation of glucose metabolic process
GO_0031670Biological processcellular response to nutrient
GO_0006885Biological processregulation of pH
GO_0010510Biological processregulation of acetyl-CoA biosynthetic process from pyruvate
GO_0006111Biological processregulation of gluconeogenesis
GO_0008286Biological processinsulin receptor signaling pathway
GO_0050848Biological processregulation of calcium-mediated signaling
GO_0072332Biological processintrinsic apoptotic signaling pathway by p53 class mediator
GO_0010565Biological processregulation of cellular ketone metabolic process
GO_0006468Biological processprotein phosphorylation
GO_0006006Biological processglucose metabolic process
GO_0042593Biological processglucose homeostasis
GO_0045254Cellular componentpyruvate dehydrogenase complex
GO_0005739Cellular componentmitochondrion
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005759Cellular componentmitochondrial matrix
GO_0042803Molecular functionprotein homodimerization activity
GO_0004740Molecular functionpyruvate dehydrogenase (acetyl-transferring) kinase activity
GO_0004672Molecular functionprotein kinase activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePDK2
Protein name[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 2) (PDH kinase 2) (PDKII)
Protein-serine/threonine kinase (EC 2.7.11.-)
SynonymsPDHK2
DescriptionFUNCTION: Kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism. Mediates cellular responses to insulin. Plays an important role in maintaining normal blood glucose levels and in metabolic adaptation to nutrient availability. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. Plays a role in the regulation of cell proliferation and in resistance to apoptosis under oxidative stress. Plays a role in p53/TP53-mediated apoptosis. .

AccessionsENST00000503176.6 [Q15119-1]
D6R983
ENST00000614357.4 [Q15119-2]
ENST00000510219.2
D6RHG2
ENST00000503614.5
ENST00000512238.1
ENST00000505440.5
D6RGV8
ENST00000508030.5
Q15119
D6RJH7
D6RDN9
ENST00000007708.7 [Q15119-2]