PDE6D report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007601Biological processvisual perception
GO_0005929Cellular componentcilium
GO_0005856Cellular componentcytoskeleton
GO_0005829Cellular componentcytosol
GO_0030659Cellular componentcytoplasmic vesicle membrane
GO_0031410Cellular componentcytoplasmic vesicle
GO_0005737Cellular componentcytoplasm
GO_0005095Molecular functionGTPase inhibitor activity
GO_0005515Molecular functionprotein binding
GO_0031267Molecular functionsmall GTPase binding

IV. Literature review

[source]
Gene namePDE6D
Protein namePhosphodiesterase 6D
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (GMP-PDE delta) (Protein p17)
SynonymshCG_32951
PDED
tmp_locus_12
DescriptionFUNCTION: Promotes the release of prenylated target proteins from cellular membranes . Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location . Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E . Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI) (By similarity). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate (By similarity). .

FUNCTION: Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate. .

AccessionsB8ZZK5
ENST00000428104.2
Q6IB24
O43924
ENST00000287600.9
C9IZ52
ENST00000409772.5