Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| pericyte | 17 studies | 26% ± 15% | |
| oligodendrocyte | 16 studies | 55% ± 15% | |
| glutamatergic neuron | 13 studies | 62% ± 24% | |
| smooth muscle cell | 13 studies | 27% ± 15% | |
| fibroblast | 11 studies | 32% ± 15% | |
| endothelial cell of lymphatic vessel | 11 studies | 47% ± 22% | |
| kidney loop of Henle epithelial cell | 7 studies | 45% ± 25% | |
| renal alpha-intercalated cell | 7 studies | 48% ± 23% | |
| endothelial cell | 6 studies | 38% ± 20% | |
| interneuron | 6 studies | 29% ± 11% | |
| GABAergic neuron | 6 studies | 35% ± 13% | |
| astrocyte | 5 studies | 43% ± 21% | |
| adipocyte | 5 studies | 24% ± 5% | |
| connective tissue cell | 5 studies | 27% ± 9% | |
| myofibroblast cell | 4 studies | 19% ± 2% | |
| neuron | 4 studies | 37% ± 12% | |
| granule cell | 4 studies | 78% ± 11% | |
| microglial cell | 4 studies | 49% ± 9% | |
| mesothelial cell | 4 studies | 46% ± 20% | |
| interstitial cell of Cajal | 3 studies | 45% ± 19% | |
| GABAergic interneuron | 3 studies | 20% ± 5% | |
| progenitor cell | 3 studies | 45% ± 15% | |
| cardiac muscle cell | 3 studies | 27% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| thymus | 100% | 2800.05 | 652 / 653 | 90% | 41.04 | 547 / 605 |
| kidney | 100% | 2631.40 | 89 / 89 | 72% | 12.75 | 647 / 901 |
| brain | 84% | 2499.56 | 2209 / 2642 | 80% | 7.92 | 563 / 705 |
| prostate | 67% | 459.21 | 163 / 245 | 83% | 3.73 | 419 / 502 |
| breast | 90% | 672.07 | 413 / 459 | 50% | 1.98 | 562 / 1118 |
| ovary | 83% | 751.36 | 149 / 180 | 50% | 4.05 | 213 / 430 |
| bladder | 95% | 1243.14 | 20 / 21 | 27% | 1.15 | 135 / 504 |
| uterus | 97% | 1303.73 | 165 / 170 | 24% | 1.89 | 109 / 459 |
| lung | 66% | 417.54 | 381 / 578 | 54% | 2.64 | 618 / 1155 |
| stomach | 69% | 554.11 | 249 / 359 | 45% | 2.76 | 129 / 286 |
| intestine | 82% | 1106.02 | 789 / 966 | 31% | 1.51 | 162 / 527 |
| adrenal gland | 70% | 453.66 | 181 / 258 | 40% | 1.96 | 93 / 230 |
| esophagus | 77% | 742.15 | 1107 / 1445 | 26% | 1.09 | 48 / 183 |
| blood vessel | 100% | 2714.10 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| adipose | 99% | 1294.72 | 1186 / 1204 | 0% | 0 | 0 / 0 |
| pancreas | 7% | 32.10 | 23 / 328 | 87% | 6.92 | 155 / 178 |
| heart | 88% | 847.37 | 761 / 861 | 0% | 0 | 0 / 0 |
| skin | 22% | 123.80 | 399 / 1809 | 21% | 1.88 | 100 / 472 |
| liver | 11% | 56.23 | 25 / 226 | 24% | 0.98 | 97 / 406 |
| spleen | 28% | 126.91 | 67 / 241 | 0% | 0 | 0 / 0 |
| muscle | 19% | 94.50 | 154 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 1% | 0.03 | 1 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0019933 | Biological process | cAMP-mediated signaling |
| GO_0034391 | Biological process | regulation of smooth muscle cell apoptotic process |
| GO_0046069 | Biological process | cGMP catabolic process |
| GO_0048660 | Biological process | regulation of smooth muscle cell proliferation |
| GO_0005829 | Cellular component | cytosol |
| GO_0043025 | Cellular component | neuronal cell body |
| GO_0004117 | Molecular function | calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity |
| GO_0005516 | Molecular function | calmodulin binding |
| GO_0048101 | Molecular function | calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity |
| GO_0046872 | Molecular function | metal ion binding |
| Gene name | PDE1A |
| Protein name | Phosphodiesterase 1A Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (Cam-PDE 1A) (EC 3.1.4.17) (61 kDa Cam-PDE) (hCam-1) Uncharacterized protein PDE1A Calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase |
| Synonyms | |
| Description | FUNCTION: Calcium/calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cGMP and cAMP, which are key regulators of many important physiological processes. Has a higher efficiency with cGMP compared to cAMP. . |
| Accessions | P54750 ENST00000358139.6 [P54750-3] Q9Y246 ENST00000482782.6 [P54750-4] Q9Y633 ENST00000410103.2 [P54750-1] Q9UNL9 ENST00000495511.2 [P54750-1] Q9Y634 ENST00000462938.6 Q53T15 ENST00000435564.6 [P54750-4] Q53TB0 A0A8Q3WKY5 ENST00000409365.6 [P54750-6] ENST00000351439.10 [P54750-2] |