PCSK1N report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016486Biological processpeptide hormone processing
GO_0007218Biological processneuropeptide signaling pathway
GO_0009409Biological processresponse to cold
GO_0002021Biological processresponse to dietary excess
GO_0005802Cellular componenttrans-Golgi network
GO_0005615Cellular componentextracellular space
GO_0030141Cellular componentsecretory granule
GO_0004866Molecular functionendopeptidase inhibitor activity
GO_0004867Molecular functionserine-type endopeptidase inhibitor activity
GO_0005102Molecular functionsignaling receptor binding

IV. Literature review

[source]
Gene namePCSK1N
Protein nameProSAAS (Proprotein convertase subtilisin/kexin type 1 inhibitor) (Proprotein convertase 1 inhibitor) (pro-SAAS) [Cleaved into: KEP; Big SAAS (b-SAAS); Little SAAS (l-SAAS) (N-proSAAS); Big PEN-LEN (b-PEN-LEN) (SAAS CT(1-49)); PEN; Little LEN (l-LEN); Big LEN (b-LEN) (SAAS CT(25-40))]
Synonyms
DescriptionFUNCTION: May function in the control of the neuroendocrine secretory pathway. Proposed be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the further processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 84 kDa form but not the autocatalytically derived 66 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. May control the intracellular timing of PCSK1 rather than its total level of activity (By similarity). .; FUNCTION: [Big LEN]: Endogenous ligand for GPR171. Neuropeptide involved in the regulation of feeding. .; FUNCTION: [PEN]: Endogenous ligand for GPR171. Neuropeptide involved in the regulation of feeding. .

AccessionsQ9UHG2
ENST00000218230.6