PCGF3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0060816Biological processrandom inactivation of X chromosome
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0031519Cellular componentPcG protein complex
GO_0035102Cellular componentPRC1 complex
GO_0005654Cellular componentnucleoplasm
GO_0000805Cellular componentX chromosome
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding
GO_0140862Molecular functionhistone H2AK119 ubiquitin ligase activity

IV. Literature review

[source]
Gene namePCGF3
Protein namePolycomb group RING finger protein 3 (RING finger protein 3A)
Polycomb group ring finger 3, isoform CRA_b (cDNA FLJ43813 fis, clone TESTI4001467, highly similar to Homo sapiens polycomb group ring finger 3 (PCGF3), mRNA)
Polycomb group ring finger 3
SynonymshCG_32383
RNF3A
RNF3
DescriptionFUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity . Plays a redundant role with PCGF5 as part of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females (By similarity). .

AccessionsA0A087WVH5
ENST00000433814.5
ENST00000470161.6 [Q3KNV8-1]
ENST00000620529.1
Q3KNV8
B3KWT8
ENST00000362003.10 [Q3KNV8-1]
ENST00000430644.5
ENST00000400151.6
ENST00000440452.5
ENST00000419774.5
F2Z3P3
B5MEC4
C9J3G7
C9JGV3
C9JYD0
ENST00000427463.5