I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| GABAergic neuron | 3 studies | 23% ± 2% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| GABAergic neuron | 3 studies | 23% ± 2% |
Insufficient scRNA-seq data for expression of PCDH8 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 76% | 1502.06 | 2013 / 2642 | 89% | 8.30 | 627 / 705 |
| prostate | 47% | 239.01 | 115 / 245 | 46% | 2.11 | 231 / 502 |
| thymus | 2% | 3.33 | 15 / 653 | 38% | 0.81 | 227 / 605 |
| adrenal gland | 0% | 0 | 0 / 258 | 20% | 1.27 | 46 / 230 |
| uterus | 2% | 4.37 | 3 / 170 | 16% | 1.57 | 72 / 459 |
| tonsil | 0% | 0 | 0 / 0 | 11% | 0.16 | 5 / 45 |
| breast | 2% | 5.07 | 11 / 459 | 8% | 0.42 | 87 / 1118 |
| lung | 0% | 0 | 0 / 578 | 7% | 0.57 | 85 / 1155 |
| esophagus | 0% | 0.27 | 2 / 1445 | 7% | 0.21 | 13 / 183 |
| stomach | 1% | 0.64 | 2 / 359 | 6% | 0.16 | 18 / 286 |
| ovary | 0% | 0 | 0 / 180 | 7% | 0.68 | 28 / 430 |
| pancreas | 0% | 0 | 0 / 328 | 5% | 0.67 | 9 / 178 |
| muscle | 4% | 8.84 | 36 / 803 | 0% | 0 | 0 / 0 |
| intestine | 1% | 1.93 | 12 / 966 | 3% | 0.08 | 15 / 527 |
| skin | 3% | 6.17 | 52 / 1809 | 1% | 0.02 | 4 / 472 |
| eye | 0% | 0 | 0 / 0 | 3% | 0.14 | 2 / 80 |
| bladder | 0% | 0 | 0 / 21 | 2% | 0.16 | 12 / 504 |
| adipose | 2% | 4.32 | 20 / 1204 | 0% | 0 | 0 / 0 |
| kidney | 0% | 0 | 0 / 89 | 1% | 0.02 | 5 / 901 |
| blood vessel | 0% | 0.63 | 5 / 1335 | 0% | 0 | 0 / 0 |
| liver | 0% | 0 | 0 / 226 | 0% | 0.01 | 1 / 406 |
| heart | 0% | 0.14 | 1 / 861 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0099179 | Biological process | regulation of synaptic membrane adhesion |
| GO_0007156 | Biological process | homophilic cell adhesion via plasma membrane adhesion molecules |
| GO_0007155 | Biological process | cell adhesion |
| GO_0007268 | Biological process | chemical synaptic transmission |
| GO_0050804 | Biological process | modulation of chemical synaptic transmission |
| GO_0001756 | Biological process | somitogenesis |
| GO_0007267 | Biological process | cell-cell signaling |
| GO_0016331 | Biological process | morphogenesis of embryonic epithelium |
| GO_0098978 | Cellular component | glutamatergic synapse |
| GO_0098685 | Cellular component | Schaffer collateral - CA1 synapse |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0042734 | Cellular component | presynaptic membrane |
| GO_0045211 | Cellular component | postsynaptic membrane |
| GO_0030425 | Cellular component | dendrite |
| GO_0005509 | Molecular function | calcium ion binding |
| Gene name | PCDH8 |
| Protein name | Protocadherin-8 (Arcadlin) |
| Synonyms | |
| Description | FUNCTION: Calcium-dependent cell-adhesion protein (By similarity). May play a role in activity-induced synaptic reorganization underlying long term memory (By similarity). Could be involved in CDH2 internalization through TAOK2/p38 MAPK pathway. In hippocampal neurons, may play a role in the down-regulation of dendritic spines, maybe through its action on CDH2 endocytosis (By similarity). . |
| Accessions | O95206 ENST00000377942.7 [O95206-1] ENST00000338862.5 [O95206-2] |
