PCBD2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0019293Biological processtyrosine biosynthetic process, by oxidation of phenylalanine
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0006729Biological processtetrahydrobiopterin biosynthetic process
GO_0005575Cellular componentcellular_component
GO_0005634Cellular componentnucleus
GO_0008124Molecular function4-alpha-hydroxytetrahydrobiopterin dehydratase activity
GO_0004505Molecular functionphenylalanine 4-monooxygenase activity
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePCBD2
Protein namePterin-4-alpha-carbinolamine dehydratase 2 (PHS 2) (EC 4.2.1.96) (4-alpha-hydroxy-tetrahydropterin dehydratase 2) (DcoH-like protein DCoHm) (Dimerization cofactor of hepatocyte nuclear factor 1 from muscle) (HNF-1-alpha dimerization cofactor)
4a-hydroxytetrahydrobiopterin dehydratase (EC 4.2.1.96)
SynonymsDCOH2
DCOHM
DescriptionFUNCTION: Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2 (By similarity). .; FUNCTION: Regulates the dimerization of homeodomain protein HNF-1-alpha and enhances its transcriptional activity. .

AccessionsQ9H0N5
H0YA52
ENST00000512783.5
ENST00000254908.11
ENST00000504352.1