PATL1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0033962Biological processP-body assembly
GO_0000290Biological processdeadenylation-dependent decapping of nuclear-transcribed mRNA
GO_0000932Cellular componentP-body
GO_0016607Cellular componentnuclear speck
GO_0030014Cellular componentCCR4-NOT complex
GO_0005829Cellular componentcytosol
GO_0036464Cellular componentcytoplasmic ribonucleoprotein granule
GO_0016605Cellular componentPML body
GO_0008266Molecular functionpoly(U) RNA binding
GO_0005515Molecular functionprotein binding
GO_0034046Molecular functionpoly(G) binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene namePATL1
Protein nameProtein PAT1 homolog 1 (PAT1-like protein 1) (Protein PAT1 homolog b) (Pat1b) (hPat1b)
SynonymsOK/KNS-cl.5
DescriptionFUNCTION: RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs . Acts as a scaffold protein that connects deadenylation and decapping machinery . Required for cytoplasmic mRNA processing body (P-body) assembly . .; FUNCTION: (Microbial infection) In case of infection, required for translation and replication of hepatitis C virus (HCV). .

AccessionsENST00000300146.10 [Q86TB9-1]
Q86TB9