I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| GABAergic neuron | 4 studies | 29% ± 10% | |
| glutamatergic neuron | 4 studies | 33% ± 10% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| GABAergic neuron | 4 studies | 29% ± 10% | |
| glutamatergic neuron | 4 studies | 33% ± 10% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 4 studies | 24% ± 7% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| breast | 100% | 963.80 | 459 / 459 | 100% | 16.28 | 1116 / 1118 |
| intestine | 100% | 1134.64 | 966 / 966 | 100% | 12.14 | 526 / 527 |
| prostate | 100% | 1178.71 | 245 / 245 | 100% | 14.69 | 501 / 502 |
| uterus | 100% | 1506.04 | 170 / 170 | 100% | 13.92 | 458 / 459 |
| thymus | 100% | 940.52 | 653 / 653 | 100% | 15.23 | 603 / 605 |
| kidney | 100% | 717.51 | 89 / 89 | 100% | 13.06 | 898 / 901 |
| esophagus | 100% | 1058.36 | 1445 / 1445 | 99% | 11.25 | 182 / 183 |
| stomach | 100% | 842.54 | 359 / 359 | 99% | 12.12 | 284 / 286 |
| liver | 100% | 848.36 | 226 / 226 | 99% | 11.34 | 403 / 406 |
| bladder | 100% | 1319.10 | 21 / 21 | 99% | 12.69 | 500 / 504 |
| pancreas | 100% | 547.61 | 327 / 328 | 99% | 11.17 | 177 / 178 |
| ovary | 100% | 1503.16 | 180 / 180 | 99% | 11.39 | 426 / 430 |
| lung | 100% | 708.07 | 576 / 578 | 99% | 12.55 | 1147 / 1155 |
| skin | 100% | 911.81 | 1809 / 1809 | 98% | 11.98 | 464 / 472 |
| brain | 98% | 505.67 | 2596 / 2642 | 100% | 9.07 | 703 / 705 |
| adrenal gland | 100% | 1226.84 | 258 / 258 | 98% | 11.40 | 225 / 230 |
| adipose | 100% | 890.71 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 941.66 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 12.21 | 29 / 29 |
| spleen | 100% | 853.98 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 12.70 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 9.26 | 1 / 1 |
| heart | 98% | 411.88 | 840 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 96% | 10.28 | 77 / 80 |
| peripheral blood | 94% | 630.30 | 870 / 929 | 0% | 0 | 0 / 0 |
| muscle | 93% | 304.87 | 750 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0034356 | Biological process | NAD biosynthesis via nicotinamide riboside salvage pathway |
| GO_1990830 | Biological process | cellular response to leukemia inhibitory factor |
| GO_2000766 | Biological process | negative regulation of cytoplasmic translation |
| GO_0030968 | Biological process | endoplasmic reticulum unfolded protein response |
| GO_0036498 | Biological process | IRE1-mediated unfolded protein response |
| GO_0019082 | Biological process | viral protein processing |
| GO_0070213 | Biological process | protein auto-ADP-ribosylation |
| GO_0016020 | Cellular component | membrane |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0071782 | Cellular component | endoplasmic reticulum tubular network |
| GO_0005635 | Cellular component | nuclear envelope |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0005829 | Cellular component | cytosol |
| GO_0016779 | Molecular function | nucleotidyltransferase activity |
| GO_0003950 | Molecular function | NAD+ ADP-ribosyltransferase activity |
| GO_0140807 | Molecular function | NAD+-protein-glutamate ADP-ribosyltransferase activity |
| GO_0019900 | Molecular function | kinase binding |
| GO_0043539 | Molecular function | protein serine/threonine kinase activator activity |
| GO_0140804 | Molecular function | NAD+- protein-lysine ADP-ribosyltransferase activity |
| GO_0140806 | Molecular function | NAD+- protein-aspartate ADP-ribosyltransferase activity |
| GO_1990404 | Molecular function | NAD+-protein ADP-ribosyltransferase activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | PARP16 |
| Protein name | Protein mono-ADP-ribosyltransferase PARP16 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 15) (Poly [ADP-ribose] polymerase 16) (PARP-16) Poly(ADP-ribose) polymerase family member 16 |
| Synonyms | C15orf30 ARTD15 |
| Description | FUNCTION: Intracellular mono-ADP-ribosyltransferase that plays a role in different processes, such as protein translation and unfolded protein response (UPR), through the mono-ADP-ribosylation of proteins involved in those processes . Acts as an inhibitor of protein translation by catalyzing mono-ADP-ribosylation of ribosomal subunits, such as RPL14 and RPS6, thereby inhibiting polysome assembly and mRNA loading . Mono-ADP-ribosylation of ribosomal subunits is promoted by NMNAT2 . Involved in the unfolded protein response (UPR) by ADP-ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors . May also mediate mono-ADP-ribosylation of karyopherin KPNB1 a nuclear import factor . May not modify proteins on arginine or cysteine residues compared to other mono-ADP-ribosyltransferases . . |
| Accessions | H3BV75 ENST00000261888.10 [Q8N5Y8-3] ENST00000444347.2 [Q8N5Y8-2] ENST00000559805.1 Q8N5Y8 ENST00000649807.2 [Q8N5Y8-1] |
