PARL report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006465Biological processsignal peptide processing
GO_0090201Biological processnegative regulation of release of cytochrome c from mitochondria
GO_1901524Biological processregulation of mitophagy
GO_0033619Biological processmembrane protein proteolysis
GO_2000377Biological processregulation of reactive oxygen species metabolic process
GO_0016485Biological processprotein processing
GO_2001243Biological processnegative regulation of intrinsic apoptotic signaling pathway
GO_0010821Biological processregulation of mitochondrion organization
GO_0008053Biological processmitochondrial fusion
GO_0030162Biological processregulation of proteolysis
GO_1903214Biological processregulation of protein targeting to mitochondrion
GO_0006508Biological processproteolysis
GO_0005743Cellular componentmitochondrial inner membrane
GO_0005739Cellular componentmitochondrion
GO_0005634Cellular componentnucleus
GO_0004175Molecular functionendopeptidase activity
GO_0005515Molecular functionprotein binding
GO_0004252Molecular functionserine-type endopeptidase activity

IV. Literature review

[source]
Gene namePARL
Protein namePresenilin-associated rhomboid-like protein, mitochondrial (EC 3.4.21.105) (Mitochondrial intramembrane cleaving protease PARL) [Cleaved into: P-beta (Pbeta)]
rhomboid protease (EC 3.4.21.105)
Presenilin-associated rhomboid-like protein, mitochondrial (EC 3.4.21.105)
SynonymsPRO2207
PSARL
DescriptionFUNCTION: Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptotic signals (By similarity). Required for the maturation of PINK1 into its 52kDa mature form after its cleavage by mitochondrial-processing peptidase (MPP) . Promotes cleavage of serine/threonine-protein phosphatase PGAM5 in damaged mitochondria in response to loss of mitochondrial membrane potential . Mediates differential cleavage of PINK1 and PGAM5 depending on the health status of mitochondria, disassociating from PINK1 and associating with PGAM5 in response to mitochondrial membrane potential loss . Required for processing of CLPB into a form with higher protein disaggregase activity by removing an autoinhibitory N-terminal peptide . Promotes processing of DIABLO/SMAC in the mitochondrion which is required for DIABLO apoptotic activity . Also required for cleavage of STARD7 and TTC19 . Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain . .

AccessionsH7C0U0
F8WCQ4
Q9H300
ENST00000450375.5
H7C122
ENST00000421484.5
ENST00000417784.5
C9JNP8
ENST00000638817.1
ENST00000639900.1
A0A1W2PS40
ENST00000449306.1
ENST00000317096.9 [Q9H300-1]
ENST00000435888.5
ENST00000311101.9 [Q9H300-2]
ENST00000639100.1
H7C045
A0A1W2PP66
ENST00000418450.5
H7C1V6