PAPSS1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001501Biological processskeletal system development
GO_0050428Biological process3'-phosphoadenosine 5'-phosphosulfate biosynthetic process
GO_0000103Biological processsulfate assimilation
GO_0005829Cellular componentcytosol
GO_0016779Molecular functionnucleotidyltransferase activity
GO_0004781Molecular functionsulfate adenylyltransferase (ATP) activity
GO_0042803Molecular functionprotein homodimerization activity
GO_0004020Molecular functionadenylylsulfate kinase activity
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene namePAPSS1
Protein namePAPSS1 protein
Uncharacterized protein PAPSS1
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 (PAPS synthase 1) (PAPSS 1) (Sulfurylase kinase 1) (SK 1) (SK1) [Includes: Sulfate adenylyltransferase (EC 2.7.7.4) (ATP-sulfurylase) (Sulfate adenylate transferase) (SAT); Adenylyl-sulfate kinase (EC 2.7.1.25) (3'-phosphoadenosine-5'-phosphosulfate synthase) (APS kinase) (Adenosine-5'-phosphosulfate 3'-phosphotransferase) (Adenylylsulfate 3'-phosphotransferase)]
SynonymsATPSK1
PAPSS
DescriptionFUNCTION: Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway . Required for normal biosynthesis of sulfated L-selectin ligands in endothelial cells . .

AccessionsENST00000265174.5
Q05BW9
O43252
Q4W5H3
Q4W5F0