PAFAH1B2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007283Biological processspermatogenesis
GO_0016042Biological processlipid catabolic process
GO_0016239Biological processpositive regulation of macroautophagy
GO_0006629Biological processlipid metabolic process
GO_0005730Cellular componentnucleolus
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0070062Cellular componentextracellular exosome
GO_0034774Cellular componentsecretory granule lumen
GO_0001650Cellular componentfibrillar center
GO_1904813Cellular componentficolin-1-rich granule lumen
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0008247Cellular component1-alkyl-2-acetylglycerophosphocholine esterase complex
GO_0042803Molecular functionprotein homodimerization activity
GO_0044877Molecular functionprotein-containing complex binding
GO_0047179Molecular functionplatelet-activating factor acetyltransferase activity
GO_0046982Molecular functionprotein heterodimerization activity
GO_0003847Molecular function1-alkyl-2-acetylglycerophosphocholine esterase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePAFAH1B2
Protein namePlatelet-activating factor acetylhydrolase IB subunit alpha2 (EC 3.1.1.47) (PAF acetylhydrolase 30 kDa subunit) (PAF-AH 30 kDa subunit) (PAF-AH subunit beta) (PAFAH subunit beta)
Platelet-activating factor acetylhydrolase IB subunit alpha2 (EC 3.1.1.47) (PAF acetylhydrolase 30 kDa subunit) (PAF-AH subunit beta)
PAFAH1B2 protein
SynonymsPAFAHB
DescriptionFUNCTION: Alpha2 catalytic subunit of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)) heterotetrameric enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and modulates the action of PAF. The activity and substrate specificity of PAF-AH (I) are affected by its subunit composition. The alpha2/alpha2 homodimer (PAFAH1B2/PAFAH1B2 homodimer) hydrolyzes PAF and 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylethanolamine (AAGPE) more efficiently than 1-O-alkyl-2-acetyl-sn-glycero-3-phosphoric acid (AAGPA). In contrast, the alpha1/alpha2 heterodimer(PAFAH1B3/PAFAH1B3 heterodimer) hydrolyzes AAGPA more efficiently than PAF, but has little hydrolytic activity towards AAGPE (By similarity). May play a role in male germ cell meiosis during the late pachytenestage and meiotic divisions as well as early spermiogenesis (By similarity). .

AccessionsENST00000527958.6 [P68402-1]
J3KNE3
ENST00000419197.6 [P68402-3]
ENST00000529887.6 [P68402-2]
ENST00000304808.10
ENST00000530272.1 [P68402-4]
Q9BUZ1
P68402