I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| classical monocyte | 8 studies | 29% ± 14% | |
| monocyte | 5 studies | 30% ± 11% | |
| neutrophil | 3 studies | 60% ± 26% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| classical monocyte | 8 studies | 29% ± 14% | |
| monocyte | 5 studies | 30% ± 11% | |
| neutrophil | 3 studies | 60% ± 26% |
Insufficient scRNA-seq data for expression of PADI4 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 99% | 977.33 | 573 / 578 | 5% | 0.19 | 62 / 1155 |
| spleen | 100% | 3678.52 | 241 / 241 | 0% | 0 | 0 / 0 |
| peripheral blood | 87% | 15134.96 | 809 / 929 | 0% | 0 | 0 / 0 |
| liver | 78% | 111.15 | 176 / 226 | 1% | 0.02 | 6 / 406 |
| kidney | 53% | 50.13 | 47 / 89 | 6% | 0.12 | 57 / 901 |
| adipose | 59% | 117.55 | 705 / 1204 | 0% | 0 | 0 / 0 |
| thymus | 45% | 41.89 | 293 / 653 | 11% | 0.66 | 68 / 605 |
| heart | 51% | 59.79 | 439 / 861 | 0% | 0 | 0 / 0 |
| breast | 35% | 31.95 | 159 / 459 | 2% | 0.10 | 26 / 1118 |
| bladder | 29% | 26.57 | 6 / 21 | 8% | 0.64 | 39 / 504 |
| brain | 28% | 28.51 | 735 / 2642 | 8% | 0.20 | 55 / 705 |
| stomach | 22% | 39.25 | 78 / 359 | 9% | 0.24 | 27 / 286 |
| uterus | 25% | 21.82 | 42 / 170 | 5% | 0.16 | 25 / 459 |
| intestine | 18% | 17.27 | 178 / 966 | 6% | 0.15 | 31 / 527 |
| esophagus | 19% | 17.46 | 281 / 1445 | 4% | 0.20 | 7 / 183 |
| prostate | 22% | 16.24 | 55 / 245 | 0% | 0.01 | 2 / 502 |
| blood vessel | 19% | 22.63 | 258 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 17% | 0.65 | 5 / 29 |
| adrenal gland | 14% | 10.90 | 36 / 258 | 3% | 0.07 | 7 / 230 |
| muscle | 15% | 8.50 | 120 / 803 | 0% | 0 | 0 / 0 |
| pancreas | 8% | 5.21 | 25 / 328 | 7% | 0.11 | 13 / 178 |
| ovary | 9% | 10.71 | 17 / 180 | 1% | 0.01 | 3 / 430 |
| skin | 7% | 5.83 | 121 / 1809 | 1% | 0.03 | 6 / 472 |
| tonsil | 0% | 0 | 0 / 0 | 7% | 0.14 | 3 / 45 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0006325 | Biological process | chromatin organization |
| GO_0045087 | Biological process | innate immune response |
| GO_0043687 | Biological process | post-translational protein modification |
| GO_0006338 | Biological process | chromatin remodeling |
| GO_0006334 | Biological process | nucleosome assembly |
| GO_0036211 | Biological process | protein modification process |
| GO_0019827 | Biological process | stem cell population maintenance |
| GO_0032991 | Cellular component | protein-containing complex |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0140796 | Molecular function | histone H3R8 arginine deiminase activity |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0140795 | Molecular function | histone H3R2 arginine deiminase activity |
| GO_0140797 | Molecular function | histone H3R17 arginine deiminase activity |
| GO_0140798 | Molecular function | histone H3R26 arginine deiminase activity |
| GO_0140794 | Molecular function | histone arginine deiminase activity |
| GO_0005509 | Molecular function | calcium ion binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0004668 | Molecular function | protein-arginine deiminase activity |
| Gene name | PADI4 |
| Protein name | Peptidyl arginine deiminase 4 (Protein-arginine deiminase type-4) Peptidyl arginine deiminase type IV Protein-arginine deiminase type-4 (EC 3.5.3.15) (HL-60 PAD) (Peptidylarginine deiminase IV) (Protein-arginine deiminase type IV) PADI4 protein Peptidyl arginine deiminase type IV (EC 3.5.3.15) |
| Synonyms | PAD4 PDI5 PADI5 |
| Description | FUNCTION: Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance . Citrullinates histone H1 at 'Arg-54' (to form H1R54ci), histone H3 at 'Arg-2', 'Arg-8', 'Arg-17' and/or 'Arg-26' (to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at 'Arg-3' (to form H4R3ci) . Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of 'Arg-54' of histone H1 (H1R54ci) results in H1 displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance . Promotes profound chromatin decondensation during the innate immune response to infection in neutrophils by mediating formation of H1R54ci . Required for the formation of neutrophil extracellular traps (NETs); NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity). Citrullination of histone H3 prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription . Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1 . . |
| Accessions | Q6EVJ7 ENST00000375453.5 Q6EVJ5 Q53HY9 Q6EVJ6 Q9UM07 ENST00000626048 Q6EVJ2 ENST00000375448.4 Q6EVJ4 Q6EVJ1 ENST00000628229.1 B1AQ67 |
