PACSIN3 | OmnibusX

Name	Number of supported studies	Average coverage
epithelial cell	3 studies	31% ± 13%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of PACSIN3 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	100%	3133.91	245 / 245	100%	93.01	501 / 502
uterus	100%	3025.15	170 / 170	99%	86.22	456 / 459
thymus	99%	2257.70	649 / 653	96%	48.07	581 / 605
breast	98%	1689.79	452 / 459	95%	54.01	1063 / 1118
ovary	100%	1917.33	180 / 180	93%	37.21	398 / 430
lung	98%	1405.72	564 / 578	94%	51.40	1088 / 1155
bladder	100%	1879.05	21 / 21	90%	55.38	453 / 504
esophagus	100%	3047.90	1445 / 1445	90%	41.54	164 / 183
skin	94%	1927.63	1699 / 1809	96%	48.67	451 / 472
adrenal gland	100%	5032.31	258 / 258	87%	44.42	200 / 230
pancreas	100%	1552.68	328 / 328	84%	26.01	150 / 178
liver	96%	1829.36	217 / 226	86%	36.85	350 / 406
stomach	99%	2304.44	356 / 359	72%	25.40	206 / 286
kidney	96%	1051.17	85 / 89	67%	15.20	605 / 901
brain	95%	1288.20	2505 / 2642	66%	13.92	463 / 705
intestine	75%	2566.94	722 / 966	74%	23.20	389 / 527
eye	0%	0	0 / 0	100%	85.48	80 / 80
muscle	100%	16407.09	803 / 803	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	82.67	45 / 45
ureter	0%	0	0 / 0	100%	65.57	1 / 1
heart	100%	6766.36	858 / 861	0%	0	0 / 0
blood vessel	99%	2192.07	1320 / 1335	0%	0	0 / 0
adipose	96%	1200.17	1161 / 1204	0%	0	0 / 0
spleen	14%	103.27	33 / 241	0%	0	0 / 0
lymph node	0%	0	0 / 0	7%	1.58	2 / 29
peripheral blood	2%	16.93	16 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0045806	Biological process	negative regulation of endocytosis
GO_0051926	Biological process	negative regulation of calcium ion transport
GO_0007010	Biological process	cytoskeleton organization
GO_0006897	Biological process	endocytosis
GO_0051044	Biological process	positive regulation of membrane protein ectodomain proteolysis
GO_0097320	Biological process	plasma membrane tubulation
GO_0030100	Biological process	regulation of endocytosis
GO_0070062	Cellular component	extracellular exosome
GO_0005768	Cellular component	endosome
GO_0005829	Cellular component	cytosol
GO_0005886	Cellular component	plasma membrane
GO_0005737	Cellular component	cytoplasm
GO_0008092	Molecular function	cytoskeletal protein binding
GO_0019855	Molecular function	calcium channel inhibitor activity
GO_0042802	Molecular function	identical protein binding
GO_0005515	Molecular function	protein binding
GO_0008289	Molecular function	lipid binding
GO_0005543	Molecular function	phospholipid binding

Gene name	PACSIN3
Protein name	Protein kinase C and casein kinase substrate in neurons protein 3 (SH3 domain-containing protein 6511) Protein kinase C and casein kinase substrate in neurons 3
Synonyms
Description	FUNCTION: Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity (By similarity). .
Accessions	ENST00000530513.5 E9PJ75 ENST00000528201.1 E9PJ33 H0YDM6 ENST00000532457.5 ENST00000533686.5 ENST00000524509.1 ENST00000525725.5 ENST00000531226.5 E9PIY1 ENST00000298838.11 A0A0C4DGG1 ENST00000528462.5 E9PQ12 ENST00000539589.5 E9PNM9 ENST00000530405.5 E9PIZ6 Q9UKS6

PACSIN3 report