P3H4 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of P3H4 at tissue level.

III. Associated gene sets

GO_0030199Biological processcollagen fibril organization
GO_0007130Biological processsynaptonemal complex assembly
GO_0046849Biological processbone remodeling
GO_0017185Biological processpeptidyl-lysine hydroxylation
GO_0032964Biological processcollagen biosynthetic process
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005730Cellular componentnucleolus
GO_0000794Cellular componentcondensed nuclear chromosome
GO_0000795Cellular componentsynaptonemal complex
GO_0005783Cellular componentendoplasmic reticulum
GO_1902494Cellular componentcatalytic complex
GO_0005518Molecular functioncollagen binding

IV. Literature review

[source]
Gene nameP3H4
Protein nameProlyl 3-hydroxylase family member 4 (inactive)
Endoplasmic reticulum protein SC65 (Leprecan-like protein 4) (Nucleolar autoantigen No55) (Prolyl 3-hydroxylase family member 4) (Synaptonemal complex protein SC65)
SynonymsSC65
NOL55
LEPREL4
DescriptionFUNCTION: Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linking of collagen fibrils. Required for normal bone density and normal skin stability via its role in hydroxylation of lysine residues in collagen alpha chains and in collagen fibril assembly. .

AccessionsENST00000592026.1
ENST00000355468.7
Q92791
ENST00000465097.1
K7ERA3
K7EJ03
H0YED7
ENST00000590496.1
ENST00000393928.6