OTUD1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0070536Biological processprotein K63-linked deubiquitination
GO_0006508Biological processproteolysis
GO_0004843Molecular functioncysteine-type deubiquitinase activity

IV. Literature review

[source]
Gene nameOTUD1
Protein nameOTU domain-containing protein 1 (EC 3.4.19.12) (DUBA-7)
SynonymsDUBA7
OTDC1
DescriptionFUNCTION: Deubiquitinating enzyme that specifically hydrolyzes 'Lys-63'-linked polyubiquitin to monoubiquitin . Required for the stability and translation of a subset mRNAs with a high abundance of rare codons by mediating deubiquitination of 40S ribosomal protein RPS10/eS10, thereby antagonizing ZNF598-mediated 40S ubiquitination . The abundance of rare codons in mRNAs can limit the translation rate and can lead to ribosome collisions that trigger activation of ribosome quality control (RQC) pathway by ZNF598 . OTUD1-mediated deubiquitination prevents activation of the RQC and subsequent dissociation of ribosomes and stimulates formation of polysomes and translation . .

AccessionsENST00000376495.5
Q5VV17