Name | Number of supported studies | Average coverage | |
---|---|---|---|
macrophage | 16 studies | 27% ± 11% | |
classical monocyte | 13 studies | 25% ± 13% | |
conventional dendritic cell | 8 studies | 26% ± 18% | |
B cell | 7 studies | 25% ± 6% | |
non-classical monocyte | 7 studies | 36% ± 17% | |
monocyte | 6 studies | 28% ± 9% | |
myeloid cell | 5 studies | 35% ± 13% | |
dendritic cell | 4 studies | 26% ± 6% | |
mononuclear phagocyte | 4 studies | 27% ± 4% | |
epithelial cell | 4 studies | 23% ± 3% | |
naive B cell | 4 studies | 26% ± 11% | |
plasma cell | 3 studies | 21% ± 4% | |
endothelial cell | 3 studies | 20% ± 2% | |
type I pneumocyte | 3 studies | 26% ± 5% | |
leukocyte | 3 studies | 23% ± 10% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
peripheral blood | 4 studies | 25% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 1028.77 | 1443 / 1445 | 100% | 30.37 | 183 / 183 |
thymus | 100% | 1302.97 | 653 / 653 | 100% | 49.96 | 604 / 605 |
ovary | 100% | 1352.95 | 180 / 180 | 100% | 33.72 | 429 / 430 |
kidney | 100% | 1208.08 | 89 / 89 | 100% | 36.67 | 898 / 901 |
lung | 100% | 2059.52 | 578 / 578 | 100% | 22.50 | 1151 / 1155 |
intestine | 100% | 1118.97 | 966 / 966 | 99% | 19.60 | 524 / 527 |
stomach | 100% | 1037.11 | 359 / 359 | 99% | 20.04 | 284 / 286 |
prostate | 100% | 872.04 | 244 / 245 | 99% | 18.03 | 499 / 502 |
breast | 100% | 1515.76 | 459 / 459 | 99% | 22.08 | 1106 / 1118 |
bladder | 100% | 1056.29 | 21 / 21 | 97% | 22.38 | 489 / 504 |
uterus | 100% | 1419.65 | 170 / 170 | 97% | 29.89 | 443 / 459 |
brain | 97% | 723.04 | 2566 / 2642 | 99% | 25.74 | 700 / 705 |
adrenal gland | 99% | 1273.96 | 256 / 258 | 95% | 16.62 | 219 / 230 |
pancreas | 95% | 509.90 | 312 / 328 | 99% | 21.45 | 176 / 178 |
skin | 97% | 2040.83 | 1756 / 1809 | 94% | 15.26 | 443 / 472 |
liver | 94% | 533.61 | 212 / 226 | 79% | 8.85 | 321 / 406 |
spleen | 100% | 1921.51 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 24.96 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 11.67 | 1 / 1 |
adipose | 100% | 1636.23 | 1203 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 1287.32 | 1333 / 1335 | 0% | 0 | 0 / 0 |
heart | 99% | 2942.22 | 855 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 99% | 18.49 | 79 / 80 |
lymph node | 0% | 0 | 0 / 0 | 97% | 22.24 | 28 / 29 |
muscle | 94% | 2305.46 | 758 / 803 | 0% | 0 | 0 / 0 |
peripheral blood | 88% | 807.18 | 821 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0070536 | Biological process | protein K63-linked deubiquitination |
GO_0006508 | Biological process | proteolysis |
GO_0004843 | Molecular function | cysteine-type deubiquitinase activity |
Gene name | OTUD1 |
Protein name | OTU domain-containing protein 1 (EC 3.4.19.12) (DUBA-7) |
Synonyms | DUBA7 OTDC1 |
Description | FUNCTION: Deubiquitinating enzyme that specifically hydrolyzes 'Lys-63'-linked polyubiquitin to monoubiquitin . Required for the stability and translation of a subset mRNAs with a high abundance of rare codons by mediating deubiquitination of 40S ribosomal protein RPS10/eS10, thereby antagonizing ZNF598-mediated 40S ubiquitination . The abundance of rare codons in mRNAs can limit the translation rate and can lead to ribosome collisions that trigger activation of ribosome quality control (RQC) pathway by ZNF598 . OTUD1-mediated deubiquitination prevents activation of the RQC and subsequent dissociation of ribosomes and stimulates formation of polysomes and translation . . |
Accessions | ENST00000376495.5 Q5VV17 |