OSGEP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0002949Biological processtRNA threonylcarbamoyladenosine modification
GO_0006400Biological processtRNA modification
GO_0000408Cellular componentEKC/KEOPS complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0061711Molecular functionN(6)-L-threonylcarbamoyladenine synthase activity
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameOSGEP
Protein nameN(6)-L-threonylcarbamoyladenine synthase (EC 2.3.1.234)
tRNA N6-adenosine threonylcarbamoyltransferase (EC 2.3.1.234) (N6-L-threonylcarbamoyladenine synthase) (t(6)A synthase) (O-sialoglycoprotein endopeptidase) (hOSGEP) (t(6)A37 threonylcarbamoyladenosine biosynthesis protein OSGEP) (tRNA threonylcarbamoyladenosine biosynthesis protein OSGEP)
SynonymsGCPL1
DescriptionFUNCTION: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. .

AccessionsQ9NPF4
ENST00000708774.1
ENST00000206542.9
ENST00000555223.5
G3V249
G3V445
ENST00000553640.3