Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| B cell | 10 studies | 20% ± 5% | |
| epithelial cell | 6 studies | 28% ± 10% | |
| macrophage | 6 studies | 19% ± 6% | |
| memory B cell | 6 studies | 17% ± 1% | |
| naive B cell | 6 studies | 21% ± 4% | |
| endothelial cell | 4 studies | 23% ± 6% | |
| natural killer cell | 4 studies | 18% ± 2% | |
| classical monocyte | 3 studies | 20% ± 3% | |
| conventional dendritic cell | 3 studies | 34% ± 12% | |
| hematopoietic precursor cell | 3 studies | 29% ± 5% | |
| non-classical monocyte | 3 studies | 19% ± 3% | |
| immature B cell | 3 studies | 19% ± 4% | |
| precursor B cell | 3 studies | 23% ± 2% | |
| dendritic cell | 3 studies | 35% ± 4% | |
| basal cell | 3 studies | 21% ± 4% | |
| transit amplifying cell | 3 studies | 23% ± 5% | |
| glutamatergic neuron | 3 studies | 27% ± 9% | |
| oligodendrocyte | 3 studies | 17% ± 1% | |
| plasmacytoid dendritic cell | 3 studies | 28% ± 8% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| bladder | 100% | 1703.38 | 21 / 21 | 100% | 20.02 | 504 / 504 |
| esophagus | 100% | 1233.87 | 1445 / 1445 | 100% | 12.52 | 183 / 183 |
| intestine | 100% | 1743.24 | 966 / 966 | 100% | 19.49 | 527 / 527 |
| lung | 100% | 1413.59 | 578 / 578 | 100% | 18.63 | 1155 / 1155 |
| prostate | 100% | 1849.02 | 245 / 245 | 100% | 16.87 | 502 / 502 |
| stomach | 100% | 1148.90 | 359 / 359 | 100% | 16.01 | 286 / 286 |
| thymus | 100% | 2134.28 | 653 / 653 | 100% | 29.92 | 605 / 605 |
| uterus | 100% | 1821.60 | 170 / 170 | 100% | 22.89 | 459 / 459 |
| brain | 100% | 1695.03 | 2639 / 2642 | 100% | 27.64 | 705 / 705 |
| kidney | 100% | 1288.11 | 89 / 89 | 100% | 14.15 | 899 / 901 |
| liver | 100% | 892.69 | 226 / 226 | 100% | 12.16 | 405 / 406 |
| skin | 100% | 1222.49 | 1808 / 1809 | 100% | 18.59 | 471 / 472 |
| ovary | 100% | 1905.48 | 180 / 180 | 100% | 16.21 | 428 / 430 |
| breast | 100% | 1429.95 | 459 / 459 | 99% | 19.15 | 1112 / 1118 |
| pancreas | 100% | 844.99 | 328 / 328 | 99% | 19.55 | 177 / 178 |
| adrenal gland | 100% | 1439.07 | 258 / 258 | 99% | 16.62 | 228 / 230 |
| adipose | 100% | 1236.97 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 33.20 | 29 / 29 |
| spleen | 100% | 2850.72 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 19.40 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 9.99 | 1 / 1 |
| blood vessel | 100% | 1299.14 | 1333 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 99% | 920.60 | 798 / 803 | 0% | 0 | 0 / 0 |
| heart | 99% | 932.66 | 852 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 99% | 15.63 | 79 / 80 |
| peripheral blood | 96% | 1053.26 | 888 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0002949 | Biological process | tRNA threonylcarbamoyladenosine modification |
| GO_0006400 | Biological process | tRNA modification |
| GO_0000408 | Cellular component | EKC/KEOPS complex |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0061711 | Molecular function | N(6)-L-threonylcarbamoyladenine synthase activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0046872 | Molecular function | metal ion binding |
| Gene name | OSGEP |
| Protein name | N(6)-L-threonylcarbamoyladenine synthase (EC 2.3.1.234) tRNA N6-adenosine threonylcarbamoyltransferase (EC 2.3.1.234) (N6-L-threonylcarbamoyladenine synthase) (t(6)A synthase) (O-sialoglycoprotein endopeptidase) (hOSGEP) (t(6)A37 threonylcarbamoyladenosine biosynthesis protein OSGEP) (tRNA threonylcarbamoyladenosine biosynthesis protein OSGEP) |
| Synonyms | GCPL1 |
| Description | FUNCTION: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. . |
| Accessions | Q9NPF4 ENST00000708774.1 ENST00000206542.9 ENST00000555223.5 G3V249 G3V445 ENST00000553640.3 |