OSBP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042531Biological processpositive regulation of tyrosine phosphorylation of STAT protein
GO_0006686Biological processsphingomyelin biosynthetic process
GO_0015914Biological processphospholipid transport
GO_1904411Biological processpositive regulation of secretory granule organization
GO_0015918Biological processsterol transport
GO_0032367Biological processintracellular cholesterol transport
GO_0035627Biological processceramide transport
GO_0035774Biological processpositive regulation of insulin secretion involved in cellular response to glucose stimulus
GO_0006699Biological processbile acid biosynthetic process
GO_0005730Cellular componentnucleolus
GO_0005886Cellular componentplasma membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005654Cellular componentnucleoplasm
GO_0097038Cellular componentperinuclear endoplasmic reticulum
GO_0005794Cellular componentGolgi apparatus
GO_0005802Cellular componenttrans-Golgi network
GO_0000139Cellular componentGolgi membrane
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0030054Cellular componentcell junction
GO_0120015Molecular functionsterol transfer activity
GO_0019904Molecular functionprotein domain specific binding
GO_0032934Molecular functionsterol binding
GO_0008142Molecular functionoxysterol binding
GO_0005515Molecular functionprotein binding
GO_0070273Molecular functionphosphatidylinositol-4-phosphate binding

IV. Literature review

[source]
Gene nameOSBP
Protein nameOxysterol-binding protein 1
Oxysterol binding protein
SynonymsOSBP1
DescriptionFUNCTION: Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum . Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol . Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly . Regulates cholesterol efflux by decreasing ABCA1 stability . .

AccessionsENST00000263847.6
H0YCV6
P22059
ENST00000525357.1