Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 7 studies | 21% ± 5% | |
endothelial cell of lymphatic vessel | 6 studies | 23% ± 8% | |
epithelial cell | 6 studies | 31% ± 12% | |
ciliated cell | 4 studies | 25% ± 8% | |
goblet cell | 4 studies | 27% ± 12% | |
lymphocyte | 3 studies | 17% ± 2% | |
GABAergic neuron | 3 studies | 35% ± 8% | |
glutamatergic neuron | 3 studies | 47% ± 10% | |
macrophage | 3 studies | 17% ± 2% | |
basal cell | 3 studies | 24% ± 7% | |
transit amplifying cell | 3 studies | 23% ± 7% | |
astrocyte | 3 studies | 21% ± 3% | |
oligodendrocyte | 3 studies | 18% ± 1% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 4 studies | 33% ± 7% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
breast | 100% | 4809.69 | 459 / 459 | 100% | 74.01 | 1118 / 1118 |
esophagus | 100% | 3920.10 | 1445 / 1445 | 100% | 57.61 | 183 / 183 |
intestine | 100% | 4586.11 | 966 / 966 | 100% | 58.32 | 527 / 527 |
liver | 100% | 7113.78 | 226 / 226 | 100% | 47.68 | 406 / 406 |
lung | 100% | 4054.93 | 578 / 578 | 100% | 51.23 | 1155 / 1155 |
pancreas | 100% | 5103.59 | 328 / 328 | 100% | 49.07 | 178 / 178 |
prostate | 100% | 4202.67 | 245 / 245 | 100% | 72.30 | 502 / 502 |
stomach | 100% | 4799.82 | 359 / 359 | 100% | 56.55 | 286 / 286 |
kidney | 100% | 4438.21 | 89 / 89 | 100% | 57.82 | 900 / 901 |
thymus | 100% | 4833.51 | 653 / 653 | 100% | 57.69 | 604 / 605 |
bladder | 100% | 4663.33 | 21 / 21 | 100% | 52.24 | 503 / 504 |
uterus | 100% | 4527.83 | 170 / 170 | 100% | 43.90 | 458 / 459 |
ovary | 100% | 4233.87 | 180 / 180 | 100% | 36.48 | 428 / 430 |
brain | 99% | 2831.94 | 2628 / 2642 | 100% | 50.36 | 705 / 705 |
adrenal gland | 100% | 10259.28 | 258 / 258 | 99% | 39.38 | 228 / 230 |
skin | 100% | 6091.03 | 1809 / 1809 | 99% | 46.76 | 467 / 472 |
adipose | 100% | 4471.49 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 4779.97 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 33.63 | 29 / 29 |
muscle | 100% | 6139.79 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 3620.69 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 45.28 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 33.08 | 1 / 1 |
eye | 0% | 0 | 0 / 0 | 99% | 36.91 | 79 / 80 |
heart | 97% | 2961.57 | 839 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 79% | 2224.79 | 736 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0042531 | Biological process | positive regulation of tyrosine phosphorylation of STAT protein |
GO_0006686 | Biological process | sphingomyelin biosynthetic process |
GO_0015914 | Biological process | phospholipid transport |
GO_1904411 | Biological process | positive regulation of secretory granule organization |
GO_0015918 | Biological process | sterol transport |
GO_0032367 | Biological process | intracellular cholesterol transport |
GO_0035627 | Biological process | ceramide transport |
GO_0035774 | Biological process | positive regulation of insulin secretion involved in cellular response to glucose stimulus |
GO_0006699 | Biological process | bile acid biosynthetic process |
GO_0005730 | Cellular component | nucleolus |
GO_0005886 | Cellular component | plasma membrane |
GO_0048471 | Cellular component | perinuclear region of cytoplasm |
GO_0016020 | Cellular component | membrane |
GO_0005789 | Cellular component | endoplasmic reticulum membrane |
GO_0005654 | Cellular component | nucleoplasm |
GO_0097038 | Cellular component | perinuclear endoplasmic reticulum |
GO_0005794 | Cellular component | Golgi apparatus |
GO_0005802 | Cellular component | trans-Golgi network |
GO_0000139 | Cellular component | Golgi membrane |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0030054 | Cellular component | cell junction |
GO_0120015 | Molecular function | sterol transfer activity |
GO_0019904 | Molecular function | protein domain specific binding |
GO_0032934 | Molecular function | sterol binding |
GO_0008142 | Molecular function | oxysterol binding |
GO_0005515 | Molecular function | protein binding |
GO_0070273 | Molecular function | phosphatidylinositol-4-phosphate binding |
Gene name | OSBP |
Protein name | Oxysterol-binding protein 1 Oxysterol binding protein |
Synonyms | OSBP1 |
Description | FUNCTION: Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum . Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol . Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly . Regulates cholesterol efflux by decreasing ABCA1 stability . . |
Accessions | ENST00000263847.6 H0YCV6 P22059 ENST00000525357.1 |