I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| epithelial cell | 4 studies | 21% ± 3% | |
| B cell | 3 studies | 16% ± 1% | |
| transit amplifying cell | 3 studies | 28% ± 6% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| epithelial cell | 4 studies | 21% ± 3% | |
| B cell | 3 studies | 16% ± 1% | |
| transit amplifying cell | 3 studies | 28% ± 6% |
Insufficient scRNA-seq data for expression of ORC6 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| skin | 94% | 330.41 | 1692 / 1809 | 93% | 9.48 | 441 / 472 |
| ovary | 83% | 64.86 | 149 / 180 | 97% | 8.53 | 418 / 430 |
| brain | 97% | 192.58 | 2560 / 2642 | 81% | 5.73 | 571 / 705 |
| lung | 86% | 93.29 | 496 / 578 | 91% | 9.62 | 1050 / 1155 |
| uterus | 78% | 54.96 | 132 / 170 | 99% | 16.49 | 454 / 459 |
| bladder | 76% | 54.67 | 16 / 21 | 98% | 12.68 | 493 / 504 |
| stomach | 73% | 82.75 | 262 / 359 | 96% | 10.18 | 274 / 286 |
| intestine | 69% | 137.85 | 671 / 966 | 96% | 11.48 | 506 / 527 |
| adrenal gland | 94% | 82.15 | 243 / 258 | 68% | 4.23 | 157 / 230 |
| esophagus | 59% | 150.43 | 854 / 1445 | 98% | 10.47 | 179 / 183 |
| breast | 60% | 40.13 | 274 / 459 | 81% | 6.59 | 907 / 1118 |
| prostate | 83% | 59.05 | 204 / 245 | 22% | 0.92 | 109 / 502 |
| kidney | 80% | 65.92 | 71 / 89 | 25% | 1.01 | 224 / 901 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 19.60 | 29 / 29 |
| spleen | 100% | 327.60 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 12.34 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 9.26 | 1 / 1 |
| pancreas | 20% | 10.69 | 65 / 328 | 77% | 4.05 | 137 / 178 |
| heart | 88% | 93.75 | 755 / 861 | 0% | 0 | 0 / 0 |
| thymus | 58% | 33.31 | 380 / 653 | 29% | 2.40 | 175 / 605 |
| liver | 28% | 32.42 | 64 / 226 | 41% | 2.17 | 168 / 406 |
| adipose | 61% | 40.86 | 735 / 1204 | 0% | 0 | 0 / 0 |
| peripheral blood | 47% | 632.39 | 440 / 929 | 0% | 0 | 0 / 0 |
| blood vessel | 37% | 20.48 | 489 / 1335 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 24% | 0.86 | 19 / 80 |
| muscle | 17% | 8.48 | 135 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0006270 | Biological process | DNA replication initiation |
| GO_0000808 | Cellular component | origin recognition complex |
| GO_0005664 | Cellular component | nuclear origin of replication recognition complex |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005829 | Cellular component | cytosol |
| GO_0016020 | Cellular component | membrane |
| GO_0001650 | Cellular component | fibrillar center |
| GO_0005634 | Cellular component | nucleus |
| GO_0003677 | Molecular function | DNA binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | ORC6 |
| Protein name | Origin recognition complex subunit 6 |
| Synonyms | ORC6L |
| Description | FUNCTION: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Does not bind histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3. . |
| Accessions | H3BT22 ENST00000219097.7 Q9Y5N6 ENST00000566860.1 ENST00000563599.5 H3BMA4 H3BTQ7 ENST00000568364.6 |
