OOEP report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of OOEP at tissue level.

III. Associated gene sets

GO_0032880Biological processregulation of protein localization
GO_0070201Biological processregulation of establishment of protein localization
GO_0008150Biological processbiological_process
GO_0051293Biological processestablishment of spindle localization
GO_0051302Biological processregulation of cell division
GO_0009880Biological processembryonic pattern specification
GO_0031297Biological processreplication fork processing
GO_0045836Biological processpositive regulation of meiotic nuclear division
GO_0007015Biological processactin filament organization
GO_1905168Biological processpositive regulation of double-strand break repair via homologous recombination
GO_0035088Biological processestablishment or maintenance of apical/basal cell polarity
GO_2000781Biological processpositive regulation of double-strand break repair
GO_0106333Cellular componentsubcortical maternal complex
GO_0032991Cellular componentprotein-containing complex
GO_0005938Cellular componentcell cortex
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameOOEP
Protein nameOocyte-expressed protein homolog (KH homology domain-containing protein 2) (Oocyte- and embryo-specific protein 19) (hOEP19)
Oocyte expressed protein
SynonymsC6orf156
KHDC2
OEP19
DescriptionFUNCTION: As part of the OOEP-KHDC3L scaffold, recruits BLM and TRIM25 to DNA replication forks, thereby promoting the ubiquitination of BLM by TRIM25, enhancing BLM retainment at replication forks and therefore promoting stalled replication fork restart (By similarity). Positively regulates the homologous recombination-mediated DNA double-strand break (DSB) repair pathway by regulating ATM activation and RAD51 recruitment to DSBs in oocytes (By similarity). Thereby contributes to oocyte survival and the resumption and completion of meiosis (By similarity). As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (By similarity). Required for the formation of F-actin cytoplasmic lattices in oocytes which in turn are responsible for symmetric division of zygotes via the regulation of mitotic spindle formation and positioning (By similarity). .

AccessionsC9J915
ENST00000370363.5
ENST00000370359.6
F2Z364
A6NGQ2
ENST00000441145.1