OARD1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042278Biological processpurine nucleoside metabolic process
GO_0006974Biological processDNA damage response
GO_0051725Biological processprotein de-ADP-ribosylation
GO_0140291Biological processpeptidyl-glutamate ADP-deribosylation
GO_0005730Cellular componentnucleolus
GO_0090734Cellular componentsite of DNA damage
GO_0005654Cellular componentnucleoplasm
GO_0061463Molecular functionO-acetyl-ADP-ribose deacetylase activity
GO_0140293Molecular functionADP-ribosylglutamate hydrolase activity
GO_0005515Molecular functionprotein binding
GO_0001883Molecular functionpurine nucleoside binding

IV. Literature review

[source]
Gene nameOARD1
Protein nameADP-ribose glycohydrolase OARD1 (O-acetyl-ADP-ribose deacetylase 1) (EC 3.5.1.-) (Terminal ADP-ribose protein glycohydrolase 1) ([Protein ADP-ribosylglutamate] hydrolase OARD1) (EC 3.2.2.-)
Chromosome 6 open reading frame 130, isoform CRA_a (O-acyl-ADP-ribose deacylase 1)
O-acyl-ADP-ribose deacylase 1
SynonymsC6orf130
TARG1
hCG_1641112
DescriptionFUNCTION: ADP-ribose glycohydrolase that hydrolyzes ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on glutamate and O-acetyl-ADP-D-ribose . Specifically acts as a glutamate mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to glutamate residues on proteins . Does not act on poly-ADP-ribosylated proteins: the poly-ADP-ribose chain of poly-ADP-ribosylated glutamate residues must by hydrolyzed into mono-ADP-ribosylated glutamate by PARG to become a substrate for OARD1 . Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins . Catalyzes the deacylation of O-acetyl-ADP-ribose, O-propionyl-ADP-ribose and O-butyryl-ADP-ribose, yielding ADP-ribose plus acetate, propionate and butyrate, respectively . .

AccessionsC9JNE2
ENST00000373154.6
ENST00000471367.1
ENST00000482853.5
ENST00000468811.5
Q9Y530
ENST00000469104.5
C9J5P1
ENST00000482515.5
ENST00000480585.5
ENST00000463088.5
C9IZY1
ENST00000464633.5
C9JXC3
H7C5Q1
ENST00000488238.5
ENST00000486443.5
ENST00000424266.7
ENST00000628419.2
C9JA90
ENST00000479950.5