Name | Number of supported studies | Average coverage | |
---|---|---|---|
ciliated cell | 8 studies | 27% ± 14% | |
B cell | 7 studies | 21% ± 6% | |
natural killer cell | 6 studies | 18% ± 2% | |
epithelial cell | 5 studies | 40% ± 15% | |
oligodendrocyte | 4 studies | 20% ± 3% | |
CD16-positive, CD56-dim natural killer cell, human | 3 studies | 16% ± 0% | |
CD4-positive, alpha-beta T cell | 3 studies | 20% ± 1% | |
hematopoietic precursor cell | 3 studies | 25% ± 12% | |
non-classical monocyte | 3 studies | 24% ± 6% | |
naive B cell | 3 studies | 17% ± 2% | |
retinal bipolar neuron | 3 studies | 27% ± 8% | |
endothelial cell | 3 studies | 28% ± 5% | |
goblet cell | 3 studies | 24% ± 9% | |
basal cell | 3 studies | 35% ± 15% | |
plasmacytoid dendritic cell | 3 studies | 21% ± 4% | |
astrocyte | 3 studies | 25% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 1210.96 | 1445 / 1445 | 100% | 10.32 | 183 / 183 |
pancreas | 100% | 1421.90 | 328 / 328 | 100% | 13.03 | 178 / 178 |
prostate | 100% | 1423.82 | 245 / 245 | 100% | 16.20 | 502 / 502 |
brain | 100% | 1219.56 | 2640 / 2642 | 100% | 15.96 | 705 / 705 |
thymus | 100% | 1733.71 | 653 / 653 | 100% | 20.46 | 604 / 605 |
lung | 100% | 1058.12 | 576 / 578 | 100% | 13.36 | 1155 / 1155 |
breast | 100% | 1500.28 | 459 / 459 | 100% | 16.09 | 1114 / 1118 |
intestine | 100% | 1333.47 | 966 / 966 | 100% | 14.45 | 525 / 527 |
ovary | 100% | 1487.62 | 180 / 180 | 100% | 10.07 | 428 / 430 |
liver | 100% | 1287.34 | 226 / 226 | 100% | 13.33 | 404 / 406 |
kidney | 100% | 1890.19 | 89 / 89 | 99% | 12.17 | 896 / 901 |
uterus | 100% | 1188.02 | 170 / 170 | 99% | 13.63 | 456 / 459 |
stomach | 100% | 1563.05 | 359 / 359 | 99% | 13.36 | 284 / 286 |
skin | 100% | 1350.03 | 1809 / 1809 | 99% | 14.92 | 468 / 472 |
bladder | 100% | 1281.71 | 21 / 21 | 99% | 11.11 | 499 / 504 |
adrenal gland | 100% | 1584.19 | 258 / 258 | 99% | 13.16 | 227 / 230 |
adipose | 100% | 1198.10 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 17.76 | 29 / 29 |
spleen | 100% | 1483.75 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 12.99 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 8.79 | 1 / 1 |
muscle | 100% | 1093.77 | 802 / 803 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 1091.16 | 1333 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 99% | 15.27 | 79 / 80 |
heart | 96% | 786.39 | 824 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 86% | 865.21 | 801 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0042278 | Biological process | purine nucleoside metabolic process |
GO_0006974 | Biological process | DNA damage response |
GO_0051725 | Biological process | protein de-ADP-ribosylation |
GO_0140291 | Biological process | peptidyl-glutamate ADP-deribosylation |
GO_0005730 | Cellular component | nucleolus |
GO_0090734 | Cellular component | site of DNA damage |
GO_0005654 | Cellular component | nucleoplasm |
GO_0061463 | Molecular function | O-acetyl-ADP-ribose deacetylase activity |
GO_0140293 | Molecular function | ADP-ribosylglutamate hydrolase activity |
GO_0005515 | Molecular function | protein binding |
GO_0001883 | Molecular function | purine nucleoside binding |
Gene name | OARD1 |
Protein name | ADP-ribose glycohydrolase OARD1 (O-acetyl-ADP-ribose deacetylase 1) (EC 3.5.1.-) (Terminal ADP-ribose protein glycohydrolase 1) ([Protein ADP-ribosylglutamate] hydrolase OARD1) (EC 3.2.2.-) Chromosome 6 open reading frame 130, isoform CRA_a (O-acyl-ADP-ribose deacylase 1) O-acyl-ADP-ribose deacylase 1 |
Synonyms | C6orf130 TARG1 hCG_1641112 |
Description | FUNCTION: ADP-ribose glycohydrolase that hydrolyzes ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on glutamate and O-acetyl-ADP-D-ribose . Specifically acts as a glutamate mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to glutamate residues on proteins . Does not act on poly-ADP-ribosylated proteins: the poly-ADP-ribose chain of poly-ADP-ribosylated glutamate residues must by hydrolyzed into mono-ADP-ribosylated glutamate by PARG to become a substrate for OARD1 . Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins . Catalyzes the deacylation of O-acetyl-ADP-ribose, O-propionyl-ADP-ribose and O-butyryl-ADP-ribose, yielding ADP-ribose plus acetate, propionate and butyrate, respectively . . |
Accessions | C9JNE2 ENST00000373154.6 ENST00000471367.1 ENST00000482853.5 ENST00000468811.5 Q9Y530 ENST00000469104.5 C9J5P1 ENST00000482515.5 ENST00000480585.5 ENST00000463088.5 C9IZY1 ENST00000464633.5 C9JXC3 H7C5Q1 ENST00000488238.5 ENST00000486443.5 ENST00000424266.7 ENST00000628419.2 C9JA90 ENST00000479950.5 |