NXF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006406Biological processmRNA export from nucleus
GO_0015031Biological processprotein transport
GO_0016973Biological processpoly(A)+ mRNA export from nucleus
GO_0042405Cellular componentnuclear inclusion body
GO_0016607Cellular componentnuclear speck
GO_0042272Cellular componentnuclear RNA export factor complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0000346Cellular componenttranscription export complex
GO_0005643Cellular componentnuclear pore
GO_0010494Cellular componentcytoplasmic stress granule
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0003729Molecular functionmRNA binding
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameNXF1
Protein nameNuclear RNA export factor 1
Nuclear RNA export factor 1 (Tip-associated protein) (Tip-associating protein) (mRNA export factor TAP)
SynonymsTAP
DescriptionFUNCTION: Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway) . The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex . ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export . Also involved in nuclear export of m6A-containing mRNAs: interaction between SRSF3 and YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export . .

AccessionsE9PLA7
B4E227
ENST00000527902.5
ENST00000530875.5
E9PMV7
H0YDU0
ENST00000294172.7 [Q9UBU9-1]
ENST00000533671.1
Q9UBU9
E9PQA4
E9PIN3
ENST00000531474.2
ENST00000531709.6 [Q9UBU9-2]
ENST00000531131.1
ENST00000532297.5 [Q9UBU9-1]
ENST00000525576.1