Name | Number of supported studies | Average coverage | |
---|---|---|---|
epithelial cell | 6 studies | 25% ± 9% | |
plasmacytoid dendritic cell | 6 studies | 22% ± 6% | |
macrophage | 5 studies | 18% ± 2% | |
endothelial cell | 4 studies | 23% ± 5% | |
astrocyte | 4 studies | 28% ± 8% | |
alveolar macrophage | 4 studies | 22% ± 8% | |
classical monocyte | 3 studies | 22% ± 2% | |
myeloid cell | 3 studies | 21% ± 5% | |
GABAergic neuron | 3 studies | 42% ± 3% | |
glutamatergic neuron | 3 studies | 51% ± 8% | |
oligodendrocyte precursor cell | 3 studies | 24% ± 7% | |
dendritic cell | 3 studies | 24% ± 7% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 1715.24 | 1445 / 1445 | 100% | 32.62 | 183 / 183 |
lung | 100% | 2036.98 | 578 / 578 | 100% | 28.13 | 1155 / 1155 |
breast | 100% | 1687.56 | 459 / 459 | 100% | 26.97 | 1117 / 1118 |
prostate | 100% | 1717.42 | 245 / 245 | 100% | 25.87 | 501 / 502 |
uterus | 100% | 1779.80 | 170 / 170 | 100% | 24.25 | 458 / 459 |
ovary | 100% | 1634.17 | 180 / 180 | 100% | 18.50 | 429 / 430 |
brain | 100% | 1420.28 | 2635 / 2642 | 100% | 20.73 | 705 / 705 |
thymus | 100% | 2278.85 | 653 / 653 | 100% | 26.35 | 602 / 605 |
pancreas | 100% | 1539.29 | 328 / 328 | 99% | 18.82 | 177 / 178 |
intestine | 100% | 1859.90 | 966 / 966 | 99% | 24.39 | 524 / 527 |
bladder | 100% | 1879.38 | 21 / 21 | 99% | 21.41 | 501 / 504 |
stomach | 100% | 1605.72 | 359 / 359 | 99% | 25.27 | 284 / 286 |
kidney | 100% | 1630.54 | 89 / 89 | 99% | 21.92 | 888 / 901 |
liver | 100% | 1770.65 | 226 / 226 | 99% | 13.33 | 400 / 406 |
adrenal gland | 100% | 1916.87 | 258 / 258 | 97% | 17.67 | 224 / 230 |
skin | 100% | 1936.46 | 1806 / 1809 | 94% | 20.25 | 443 / 472 |
adipose | 100% | 1770.68 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 1961.13 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 17.88 | 29 / 29 |
spleen | 100% | 1776.79 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 22.13 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 4.85 | 1 / 1 |
muscle | 99% | 782.96 | 795 / 803 | 0% | 0 | 0 / 0 |
heart | 98% | 971.23 | 846 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 78% | 8.75 | 62 / 80 |
peripheral blood | 73% | 1378.22 | 675 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0001525 | Biological process | angiogenesis |
GO_0006489 | Biological process | dolichyl diphosphate biosynthetic process |
GO_0051000 | Biological process | positive regulation of nitric-oxide synthase activity |
GO_0035268 | Biological process | protein mannosylation |
GO_0006486 | Biological process | protein glycosylation |
GO_0019408 | Biological process | dolichol biosynthetic process |
GO_0030154 | Biological process | cell differentiation |
GO_0038084 | Biological process | vascular endothelial growth factor signaling pathway |
GO_0043536 | Biological process | positive regulation of blood vessel endothelial cell migration |
GO_0032383 | Biological process | regulation of intracellular cholesterol transport |
GO_0042632 | Biological process | cholesterol homeostasis |
GO_1904423 | Cellular component | dehydrodolichyl diphosphate synthase complex |
GO_0005789 | Cellular component | endoplasmic reticulum membrane |
GO_0045547 | Molecular function | dehydrodolichyl diphosphate synthase activity |
GO_0005515 | Molecular function | protein binding |
GO_0004659 | Molecular function | prenyltransferase activity |
GO_0046872 | Molecular function | metal ion binding |
Gene name | NUS1 |
Protein name | Dehydrodolichyl diphosphate synthase complex subunit NUS1 (EC 2.5.1.87) (Cis-prenyltransferase subunit NgBR) (Nogo-B receptor) (NgBR) (Nuclear undecaprenyl pyrophosphate synthase 1 homolog) |
Synonyms | NGBR C6orf68 |
Description | FUNCTION: With DHDDS, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Both subunits contribute to enzymatic activity, i.e. condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER) . Synthesizes long-chain polyprenols, mostly of C95 and C100 chain length . Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol. Acts as a specific receptor for the N-terminus of Nogo-B, a neural and cardiovascular regulator . . |
Accessions | Q96E22 ENST00000368494.4 |