NUS1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001525Biological processangiogenesis
GO_0006489Biological processdolichyl diphosphate biosynthetic process
GO_0051000Biological processpositive regulation of nitric-oxide synthase activity
GO_0035268Biological processprotein mannosylation
GO_0006486Biological processprotein glycosylation
GO_0019408Biological processdolichol biosynthetic process
GO_0030154Biological processcell differentiation
GO_0038084Biological processvascular endothelial growth factor signaling pathway
GO_0043536Biological processpositive regulation of blood vessel endothelial cell migration
GO_0032383Biological processregulation of intracellular cholesterol transport
GO_0042632Biological processcholesterol homeostasis
GO_1904423Cellular componentdehydrodolichyl diphosphate synthase complex
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0045547Molecular functiondehydrodolichyl diphosphate synthase activity
GO_0005515Molecular functionprotein binding
GO_0004659Molecular functionprenyltransferase activity
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameNUS1
Protein nameDehydrodolichyl diphosphate synthase complex subunit NUS1 (EC 2.5.1.87) (Cis-prenyltransferase subunit NgBR) (Nogo-B receptor) (NgBR) (Nuclear undecaprenyl pyrophosphate synthase 1 homolog)
SynonymsNGBR
C6orf68
DescriptionFUNCTION: With DHDDS, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Both subunits contribute to enzymatic activity, i.e. condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER) . Synthesizes long-chain polyprenols, mostly of C95 and C100 chain length . Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol. Acts as a specific receptor for the N-terminus of Nogo-B, a neural and cardiovascular regulator . .

AccessionsQ96E22
ENST00000368494.4