NUDT16 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_2000233Biological processnegative regulation of rRNA processing
GO_0090068Biological processpositive regulation of cell cycle process
GO_0006402Biological processmRNA catabolic process
GO_0035863Biological processdITP catabolic process
GO_0110155Biological processNAD-cap decapping
GO_0016077Biological processsno(s)RNA catabolic process
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0097383Molecular functiondIDP phosphatase activity
GO_1990174Molecular functionphosphodiesterase decapping endonuclease activity
GO_0031404Molecular functionchloride ion binding
GO_0110153Molecular functionRNA NAD-cap (NMN-forming) hydrolase activity
GO_0140933Molecular function5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
GO_0042802Molecular functionidentical protein binding
GO_0003729Molecular functionmRNA binding
GO_0000287Molecular functionmagnesium ion binding
GO_0000166Molecular functionnucleotide binding
GO_0030145Molecular functionmanganese ion binding
GO_0030515Molecular functionsnoRNA binding
GO_0050897Molecular functioncobalt ion binding
GO_1990003Molecular functionIDP phosphatase activity
GO_0035870Molecular functiondITP diphosphatase activity
GO_0008235Molecular functionmetalloexopeptidase activity

IV. Literature review

[source]
Gene nameNUDT16
Protein nameU8 snoRNA-decapping enzyme (EC 3.6.1.62) (IDP phosphatase) (IDPase) (EC 3.6.1.64) (Inosine diphosphate phosphatase) (Nucleoside diphosphate-linked moiety X motif 16) (Nudix motif 16) (Nudix hydrolase 16) (U8 snoRNA-binding protein H29K) (m7GpppN-mRNA hydrolase)
Synonyms
DescriptionFUNCTION: RNA-binding and decapping enzyme that catalyzes the cleavage of the cap structure of snoRNAs and mRNAs in a metal-dependent manner. Part of the U8 snoRNP complex that is required for the accumulation of mature 5.8S and 28S rRNA. Has diphosphatase activity and removes m7G and/or m227G caps from U8 snoRNA and leaves a 5'monophosphate on the RNA. Catalyzes also the cleavage of the cap structure on mRNAs. Does not hydrolyze cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG). Also hydrolysis m7G- and m227G U3-capped RNAs but with less efficiencies. Has broad substrate specificity with manganese or cobalt as cofactor and can act on various RNA species. Binds to the U8 snoRNA; metal is not required for RNA-binding. May play a role in the regulation of snoRNAs and mRNAs degradation. Acts also as a phosphatase; hydrolyzes the non-canonical purine nucleotides inosine diphosphate (IDP) and deoxyinosine diphosphate (dITP) as well as guanosine diphosphate (GDP), deoxyguanosine diphosphate (dGDP), xanthine diphosphate (XDP), inosine triphosphate (ITP) and deoxyinosine triphosphate (ITP) to their respective monophosphate derivatives and does not distinguish between the deoxy- and ribose forms . The order of activity with different substrates is IDP > dIDP >> GDP = dGDP > XDP = ITP = dITP . Binds strongly to GTP, ITP and XTP. Participates in the hydrolysis of dIDP/IDP and probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions . Exhibits decapping activity towards NAD-capped RNAs and FAD-capped RNAs . Exhibits decapping activity towards dpCoA-capped RNAs in vitro (By similarity). .

AccessionsENST00000537561.5 [Q96DE0-3]
ENST00000521288.2 [Q96DE0-1]
Q96DE0
ENST00000502852.1 [Q96DE0-4]