RNA NAD-cap (NMN-forming) hydrolase activity

I. Literature review

[source]
NameRNA NAD-cap (NMN-forming) hydrolase activity
IDGO_0110153
collection_id

Molecular function

Description

Catalysis of the reaction: a 5'-end NAD+-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + beta-nicotinamide D-ribonucleotide + 2 H+.

Comment

This reaction specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA.

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Genes